Review

. 2025:1469:375-394.

doi: 10.1007/978-3-031-82990-1_16.

Extracellular Vesicles in the Aging Male Reproductive System: Progresses and Perspectives

Wenbo Li^#^{1

2

3

4}, Ziwen Yu^#¹, Shuai Xu^{2

3

4}, Zheng Li^{5

6

7

8}, Weiliang Xia^{9

10}

Affiliations

¹ School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.
² Depart. of Andrology, Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Shanghai Key Lab of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴ Depart. of ART, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁵ Depart. of Andrology, Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lizhengboshi@sjtu.edu.cn.
⁶ Shanghai Key Lab of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lizhengboshi@sjtu.edu.cn.
⁷ Depart. of ART, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lizhengboshi@sjtu.edu.cn.
⁸ Bengbu Hospital of Shanghai General Hospital (The Second Affiliated Hospital of Bengbu Medical University), Bengbu, Anhui, China. lizhengboshi@sjtu.edu.cn.
⁹ School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China. wlxia@sjtu.edu.cn.
¹⁰ State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wlxia@sjtu.edu.cn.

^# Contributed equally.

PMID: 40301265
DOI: 10.1007/978-3-031-82990-1_16

Review

Extracellular Vesicles in the Aging Male Reproductive System: Progresses and Perspectives

Wenbo Li et al. Adv Exp Med Biol. 2025.

. 2025:1469:375-394.

doi: 10.1007/978-3-031-82990-1_16.

Authors

Wenbo Li^#^{1

2

3

4}, Ziwen Yu^#¹, Shuai Xu^{2

3

4}, Zheng Li^{5

6

7

8}, Weiliang Xia^{9

10}

Affiliations

¹ School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.
² Depart. of Andrology, Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Shanghai Key Lab of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴ Depart. of ART, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁵ Depart. of Andrology, Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lizhengboshi@sjtu.edu.cn.
⁶ Shanghai Key Lab of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lizhengboshi@sjtu.edu.cn.
⁷ Depart. of ART, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lizhengboshi@sjtu.edu.cn.
⁸ Bengbu Hospital of Shanghai General Hospital (The Second Affiliated Hospital of Bengbu Medical University), Bengbu, Anhui, China. lizhengboshi@sjtu.edu.cn.
⁹ School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China. wlxia@sjtu.edu.cn.
¹⁰ State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wlxia@sjtu.edu.cn.

^# Contributed equally.

PMID: 40301265
DOI: 10.1007/978-3-031-82990-1_16

Abstract

Extracellular vesicles (EVs) serve as crucial mediators of intercellular communication in spermatogenesis, steroidogenesis, and age-related pathophysiological processes within the male reproductive system. These EVs exhibit promising prospects for disease diagnosis and therapeutic administration. This review explores the impact of advanced paternal age on male fertility and testosterone decline, shedding light on the underlying mechanisms. It highlights the decline in semen quality, DNA damage, and alterations in sperm miRNA profiles associated with aging. The interplay between oxidative stress and antioxidants crucially regulates male reproductive aging. Currently, most studies focus on Sertoli cell-derived EVs, while understanding of Leydig cell-derived vesicles remains limited. Multi-omics integration will enhance the understanding of male reproductive aging and guide personalized interventions, revealing potential biomarkers and targets in the future.

Keywords: Aging; Extracellular vesicle; Male reproductive system; Spermatogenesis; Testicular microenvironment.

PubMed Disclaimer

References

1. Aitken, R.J.: The changing tide of human fertility. Hum. Reprod. 37(4), 629–638 (2022). https://doi.org/10.1093/humrep/deac011 - DOI - PubMed - PMC
1. Johnson, J.A., Tough, S., Wilson, R.D., et al.: Delayed child-bearing. J. Obstet. Gynaecol. Can. 34(1), 80–93 (2012). https://doi.org/10.1016/S1701-2163(16)35138-6 - DOI - PubMed
1. Kaufman, J.M., Lapauw, B., Mahmoud, A., T’Sjoen, G., Huhtaniemi, I.T.: Aging and the male reproductive system. Endocr. Rev. 40(4), 906–972 (2019). https://doi.org/10.1210/er.2018-00178 - DOI - PubMed
1. Aitken, R.J.: Male reproductive ageing: a radical road to ruin. Hum. Reprod. 38(10), 1861–1871 (2023). https://doi.org/10.1093/humrep/dead157 - DOI - PubMed - PMC
1. Ho, C.K.M., Habib, F.K.: Estrogen and androgen signaling in the pathogenesis of BPH. Nat. Rev. Urol. 8(1), 29–41 (2011). https://doi.org/10.1038/nrurol.2010.207 - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Extracellular Vesicles in the Aging Male Reproductive System: Progresses and Perspectives

Affiliations

Extracellular Vesicles in the Aging Male Reproductive System: Progresses and Perspectives

Authors

Affiliations

Abstract

Similar articles

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Abstract

Similar articles

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical