Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 29;25(1):309.
doi: 10.1186/s12876-025-03806-1.

Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China

Ying Wan  1   2 , Yongmei Wu  3 , Yunran Yang  4 , Qingqing Zhou  1 , Yu Li  1 , Da Wang  1 , Dan Zhang  5 , Kunpeng Na  6 , Lan Liu  3 , Yule He  1 , Hang Chen  1 , Minshan Huang  1 , Le Cai  7 , Dingyun You  8 , Lanqing Ma  9
Affiliations

Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China

Ying Wan et al. BMC Gastroenterol. .

Abstract

Background: The status of family-based H. pylori infection in Yunnan Province is unknown. This study is the first family-based epidemiological survey of H. pylori in the province, aiming to provide new insights into the status of family-based H. pylori infections in Yunnan Province as well as in the country as a whole.

Methods: Between 2021 and 2023, 1,176 families with 2,947 family members were tested for H. pylori in six cities in Yunnan Province with different geographic locations and economic status, to assess the status of H. pylori infection, and to clarify the related factors and modes of transmission by means of a questionnaire survey.

Results: In Yunnan Province, the H. pylori infection rate was 31.46% (927/2947) in people and 54.59% (642/1176) in families.On the individual side, living outside of southern Yunnan (e.g., Central OR 1.41, 95% CI 1.10-1.81), having a family member living together for ≥ 1 year (OR 2.43, 95% CI 1.49-3.95), being ≥ 18 years old (e.g., 18-44 years old: OR 3.51, 95% CI 1.98-6.23), and gastrointestinal discomfort within the last 1 year (OR 1.25, 95% CI 1.04-1.50) were independent risk factors for H. pylori infection in the study population in Yunnan Province, whereas an education level of college/university and above (OR 0.62, 95% CI 0.48-0.79), and a gastroscopy within 5 years (OR 0.58, 95% CI 0.46-0.73) were independent protective factors for their H. pylori infection. In terms of family, living outside of southern Yunnan (e.g., Central OR 1.52, 95% CI 1.07-2.18), and having ≥ 3 people living together in the family (e.g., 3-4 people: OR 2.04, 95% CI 1.52-2.72) were independent risk factors for H. pylori infection in study families in Yunnan Province, whereas an annual household income of ≥ 100,000 ( OR 0.68, 95% CI 0.51-0.90), total household living area ≥ 60 m2 (OR 0.62, 95% CI 0.39-0.97), the use of separate meals for intra-household gatherings (OR 0.56, 95% CI 0.38-0.85), and the use of communal spoons and chopsticks (OR 0.38, 95% CI 0.28-0.52) were the independent protective factorse.

Conclusion: The risk factors of Family-Based H. pylori infection in Yunnan province were closely related to demographic characteristics, personal and family living habits. Close contact with infected family members may be the main cause of transmission. Family-based control of H. pylori infection should be regarded in clinical practice.

Keywords: Epidemiological; Ethnic minority; Family-based; Helicobacter pylori; Risk factors.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was conducted in strict accordance with the Declaration of Helsinki.The study was approved by the Ethics Committee of the First Affiliated Hospital of Kunming Medical University, and all enrolled participants or their guardians complied with the voluntary principle and signed the relevant informed consent forms. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Study area distribution in yunnan province
Fig. 2
Fig. 2
Helicobacter pylori infection Status in patients of different ages
Fig. 3
Fig. 3
Helicobacter pylori infection Status in different family size
Fig. 4
Fig. 4
H. pylori infection status in different geographical locations. (A) Individual H. pylori infection status in different geographical locations. **p < 0.01, ***p < 0.001 when infection rates between the two groups were compared; ns, not significant when these groups were compared with each other, p > 0.05. (B) Household H. pylori infection status in different geographical locations.**p < 0.01, ***p < 0.001 when infection rates between the two groups were compared; ns, not significant when these groups were compared with each other, p > 0.05
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis [J]. Lancet. 1983;1(8336):1273–5. - PubMed
    1. Malfertheiner P, Megraud F, Rokkas T, Gisbert JP, Liou JM, Schulz C, Gasbarrini A, Hunt RH, Leja M, O’Morain C, Rugge M, Suerbaum S, Tilg H, Sugano K, El-Omar EM. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report [J]. Gut, 2022.
    1. Santos MLC, de Brito BB, da Silva FA, F, Sampaio MM, Marques HS. Oliveira E S N, de Magalhaes Queiroz D M, de Melo F F. Helicobacter pylori infection: beyond gastric manifestations [J]. World J Gastroenterol. 2020;26(28):4076–93. - PMC - PubMed
    1. Group H p, Gastroenterology S, o CS, Association CM. Sixth Chinese National consensus report on the management of Helicobacter pylori infection(treatment excluded) [J]. Chin J Dig. 2022;42(05):289–303.
    1. Camilo V, Sugiyama T, Touati E. Pathogenesis of Helicobacter pylori infection [J]. Helicobacter. 2017;22(S1):e12405. - PubMed