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Comparative Study
. 2025 Apr 29;25(1):189.
doi: 10.1186/s12893-025-02906-9.

Comparison of rapid recovery outcomes between vNOTES hysterectomy and laparoscopic hysterectomy: a prospective study

Ying Tang #  1   2 , Chun-Ling Fang #  1   3 , Jun-Rong Huang #  1   3 , Xiao-Mei Chen  1   3 , Xin Cai  1 , Jia Wu  1 , Hui-Quan Hu  1 , Jun Li  1 , Yue-Xi Luo  4
Affiliations
Comparative Study

Comparison of rapid recovery outcomes between vNOTES hysterectomy and laparoscopic hysterectomy: a prospective study

Ying Tang et al. BMC Surg. .

Abstract

Background: This study was aimed at evaluating the postoperative outcomes of vaginal natural orifice transluminal endoscopic hysterectomy (vNOTEH).

Methods: This prospective cohort study was conducted for comparing recovery outcomes, the time to first anal exhaust and return-to-work (RTW) time in vNOTEH versus laparoscopic hysterectomy (LH) groups. Linear regression analysis and cox proportional hazards regression were employed for analyzing the association between the recovery outcomes and surgical procedures.

Results: Altogether 330 patients were enrolled, with 92 in vNOTEH group whereas 238 in LH group according to the surgical procedure. Among them, 22 patients undergoing vNOTEH and 76 patients receiving LH returned to work. The operation time, the first anal exhaust time, RTW time, postoperative hospitalization of vNOTEH group remarkably decreased relative to LH group (P<0.05). Linear regression analysis indicated that the vNOTES approach was related to the time to first anal exhaust. Besides, Kaplan-Meier curve demonstrated the shorter median time to first anal exhaust in vNOTEH group than that in LH group (48.0 h vs. 69.0 h, P < 0.001). For patients who returned to work, multivariate Cox logistic regression revealed that surgical approach and postoperative hospitalization were significantly related to the RTW time. Furthermore, Kaplan-Meier curve showed that the median RTW time significantly decreased in vNOTEH subgroup relative to that in LH subgroup (2.0 months vs.3.0 months, P = 0.011).

Conclusions and relevance: vNOTES in women might be advantageous in the earlier recovery of intestinal function and the earlier return to work after hysterectomy compared with laparoscopy.

Trial registration: This study has been registered at https://www.chictr.org.cn with registration NO. ChiCTR2200063125 on Sep 27, 2022. The minimal postoperative follow up period was 1 month.

Keywords: Benign uterus disease; First anal exhaust; Hysterectomy; Return to work; vNOTES.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The written informed consent was acquired from each participant to gather their data anonymously for research purpose. The approval of this study was obtained from Ethics Committee of the Affiliated Nanchong Central Hospital of North Sichuan Medical College (No. 2022066). All procedures performed in studies involving human participants were in accordance with the 1963 Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of patient selection
Fig. 2
Fig. 2
Recovery outcomes for patients underwent vNOTES hysterectomy.A, the estimated median time to first anal exhaust was shorter in vNOTEH group than that in laparoscopic hysterectomy group (50.8 hours vs. 70.2 hours, P＜0.001); B, the median time to return to work was shorter in vNOTEH subgroup than that in LH subgroup (2.4 months vs. 4.0 months, P=0.011) (vNOTEH, Vaginal Natural Orifice Transluminal Endoscopic hysterectomy).
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