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Review
. 2025 Jan 2;10(4):1011-1019.
doi: 10.1016/j.ekir.2024.12.035. eCollection 2025 Apr.

Overview of ADPKD in Pregnancy

Ruth E Campbell  1 , Charles L Edelstein  1 , Michel Chonchol  1
Affiliations
Review

Overview of ADPKD in Pregnancy

Ruth E Campbell et al. Kidney Int Rep. .

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disorder that often affects patients in their third to fifth decades of life and is characterized by kidney cysts, chronic kidney disease (CKD), hypertension, and hepatic cysts. The development of clinical symptoms often coincides with childbearing years. Consequently, there are several considerations regarding pregnant patients with ADPKD. In this review, we detail the effects and management of ADPKD in the peripartum period and discuss family planning options, including assisted reproductive techniques (ART) and preimplantation genetic testing.

Keywords: ADPKD; pregnancy; preimplantation genetic testing.

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Figures

Figure 1
Figure 1
Preimplantation genetic testing. Embryos are created through either IVF or ICSI. The blastocyst is then biopsied, and the mutation of interest is identified. An embryo without the mutation is implanted into the mother. Created in BioRender. Campbell, R. (2024) https://BioRender.com/m16w704.IVF, in vitro fertilization; ICSI, intracytoplasmic sperm insertion.
See this image and copyright information in PMC

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