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. 2023 Dec 16:2023:9201177.
doi: 10.1155/2023/9201177. eCollection 2023.

Regional Cross-Sectional Based Study and Associated Risk Factors of Porcine Circovirus 2 in Nigerian Pigs

Kayode O Afolabi  1   2 , Olufemi S Amoo  3 , Tochukwu I Onuigbo  3 , Joy I Oraegbu  3 , Ayomikun A Awoseyi  4 , Folorunso O Fasina  5   6 , Oluwawemimo O Adebowale  7
Affiliations

Regional Cross-Sectional Based Study and Associated Risk Factors of Porcine Circovirus 2 in Nigerian Pigs

Kayode O Afolabi et al. Transbound Emerg Dis. .

Erratum in

Abstract

Porcine circovirus 2 (PCV2) is a swine viral pathogen of substantial economic importance in pig farming globally. However, large-scale surveillance is needed to determine its prevalence and associated risk factors in the Nigerian pigs. We conducted molecular-based surveillance and mapping of PCV2 in southwest Nigeria to assess its prevalence and spatiality. Six hundred forty-eight individual fecal samples were collected from the different age groups of pigs from 67 farms in three southwest states. The polymerase chain reaction technique was used to screen the samples with a specific primer pair. The viral prevalence was determined at individual animal and farm levels. Overall, 145 out of 648 samples (22.4%) and 49/67 farms (73.1%) tested positive for PCV2. The highest prevalence of PCV2 was observed in Oyo State (63/185, 34.1%) and in growers (66/145, 45.5%). Restricting visitors' entrance to the farm was found to be strongly protective for PCV2 (AOR 0.122; p=0.007; 95% CI; 0.027-0.564), while not having a quarantine protocol (AOR 4.445; p=0.041; 95% CI; 1.067-18.5280) and reporting coccidiosis as a common disease encountered (AOR 14.340; p=0.007; 95% CI; 2.094-98.203) on the farm were significant risk factors identified to be associated with the presence of PCV2. This study revealed a higher prevalence of PCV2 in Nigerian swine herds than expected and presented significant spatial clustering of infection in the studied region. It has also highlighted the risk factors driving its spread in the studied area. The research findings underscore the need for a policy decision to promote PCV2 vaccination in the country, which is currently not in place. The availability and use of the PCV2 vaccines, in addition to effective biosecurity measures, will help to mitigate the virus and its associated diseases in the country for sustainable and profitable pig farming, which holds vast potential in solving the problem of hunger and poverty.

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Conflict of interest statement

The authors declare that there is no competing interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Geospatial presentation of study locations investigated for PCV2.
Figure 2
Figure 2
(a) Common diseases encountered among pigs and (b) antimicrobial use pattern among pig farms in Southwest Nigeria.
Figure 3
Figure 3
Phylogenetic tree showing three PCV2 sequences (in black dots) generated from the molecular screening exercise and the related reference sequences obtained from NCBI GenBank. The neighbour-joining method was used, and bootstrap values ≥80% are shown. A reference PCV1 (PCU49186) was used as an outlier.
Figure 4
Figure 4
Hot spots (color-coded red) for PCV-2 in the sampled areas of Southwest Nigeria.
Figure 5
Figure 5
(a–d) Autocorrelation analysis of sampling sites for PCV2 in Southwest Nigeria.
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