A human immunoglobulin in myeloma protein with anti-gastric parietal cell autoantigen activity
- PMID: 403042
- PMCID: PMC1540901
A human immunoglobulin in myeloma protein with anti-gastric parietal cell autoantigen activity
Abstract
A previously characterised IgA Kappa myeloma protein was isolated and purified. The (Fab) alpha fragments of this immunoglobulin were obtained. The IgA and Fab fragments reacted in vitro with gastric parietal cells (GPC) using animal gastric sections and with smooth cytoplasmic membranes obtained from rabbit fundus (gastric) mucosa. This was seen macroscopically and by light and electron microscopy. Evidence is thus provided which supports the concept that this homogeneous immunoglobulin is a typical monoclonal autoantibody.
Similar articles
-
Normal human sera contain antibodies directed at Fab of IgA.J Immunol. 1987 Apr 1;138(7):2244-8. J Immunol. 1987. PMID: 3494062
-
Functional humanization of an anti-CD16 Fab fragment: obstacles of switching from murine {lambda} to human {lambda} or {kappa} light chains.Protein Eng Des Sel. 2009 Mar;22(3):175-88. doi: 10.1093/protein/gzn066. Epub 2008 Nov 19. Protein Eng Des Sel. 2009. PMID: 19022801
-
Characterization of an antiserum specific for the Fabalpha fragment. Its use for detection of alpha-heavy chain disease protein by immunoselection.J Immunol. 1979 Jan;122(1):19-23. J Immunol. 1979. PMID: 762416
-
Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody.J Mol Recognit. 1999 Jan-Feb;12(1):19-32. doi: 10.1002/(SICI)1099-1352(199901/02)12:1<19::AID-JMR445>3.0.CO;2-Y. J Mol Recognit. 1999. PMID: 10398393 Review.
-
Structure of human immunoglobulins: myeloma proteins as analogues of antibody.Prog Allergy. 1970;14:1-36. Prog Allergy. 1970. PMID: 4116725 Review. No abstract available.
Cited by
-
Monoclonal cryoimmunoglobulin with anti-cytomegalovirus activity associated with T cell chronic lymphocytic leukaemia.Clin Exp Immunol. 1980 Aug;41(2):317-25. Clin Exp Immunol. 1980. PMID: 6254708 Free PMC article.
-
A transient monoclonal human IgG1 kappa protein with anti-thyroglobulin activity: lack of cross-idiotypy with polyclonal anti-thyroglobulin antibodies.Clin Exp Immunol. 1981 Nov;46(2):268-76. Clin Exp Immunol. 1981. PMID: 6802537 Free PMC article.
-
A monoclonal macroglobulin with antinuclear activity.J Clin Pathol. 1979 May;32(5):450-4. doi: 10.1136/jcp.32.5.450. J Clin Pathol. 1979. PMID: 112123 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous