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Practice Guideline
. 2025 Jun;52(6):e481-e528.
doi: 10.1111/1346-8138.17746. Epub 2025 Apr 30.

Wound, Pressure Ulcer and Burn Guidelines (2023)-5: Guidelines for the Management of Lower Leg Ulcers/Varicose Veins, Third Edition Wound/Pressure Ulcer/Burn Guidelines Drafting Committee (Lower Leg Ulcers/Varicose Veins Group)

Takeo Maekawa  1 , Takaaki Ito  2 , Takeo Idezuki  3 , Mayumi Ota  4 , Hiroshi Sakai  5 , Yasuko Sarayama  6 , Takamitsu Tanaka  7 , Hiroyuki Niihara  8 , Takayuki Fusumae  9 , Koji Makino  10 , Hiroshi Yatsushiro  11 , Akiyo Kondo  3 , Yoshihide Asano  12 , Takeshi Nakanishi  13 , Sei-Ichiro Motegi  14 , Yuichiro Yoshino  15 , Hiroshi Fujiwara  16 , Minoru Hasegawa  17 , Manabu Fujimoto  5 , Takao Tachibana  18
Affiliations
Practice Guideline

Wound, Pressure Ulcer and Burn Guidelines (2023)-5: Guidelines for the Management of Lower Leg Ulcers/Varicose Veins, Third Edition Wound/Pressure Ulcer/Burn Guidelines Drafting Committee (Lower Leg Ulcers/Varicose Veins Group)

Takeo Maekawa et al. J Dermatol. 2025 Jun.

Abstract

Guidelines for the management of lower leg ulcers/varicose veins, third edition is a fully revised guideline drafted by the Japanese Dermatological Association Wound/Pressure Ulcer/Burn Guidelines Drafting Committee. They were developed in a systematic and transparent manner with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. In the four clinical questions with meta-analyses, ultrasonography, compression therapy, surgical therapy, and sclerotherapy were weakly recommended in the treatment of lower leg ulcers/varicose veins. General information on diagnosis, prevention, assessment, and unconventional treatment of lower leg ulcers/varicose veins was also provided.

Keywords: compression therapy; lower leg ulcers; sclerotherapy; surgical therapy; ultrasonography; varicose veins; venous hypertension; venous insufficiency.

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References

    1. T. Ito, R. Kukino, Y. Sarayama, et al., “The Wound/Pressure Ulcer/Burn Guidelines – 5: Guidelines for the Management of Lower Leg Ulcers/Varicose Veins,” Journal of Dermatology 10 (2017): 2239–2259.
    1. https://www.kekkangeka.com/blog/1267/.
    1. P. H. Carpentier, H. R. Maricq, C. Biro, C. O. Ponçot‐Makinen, and A. Franco, “Prevalence Risk Factors and Clinical Patterns of Chronic Venous Disorders of Lower Limbs: A Population‐Based Study in France,” Journal of Vascular Surgery 40 (2004): 650–659.
    1. R. M. Kaplan, M. H. Criqui, J. O. Denenberg, J. Bergan, and A. Fronek, “Quality of Life in Patients With Chronic Venous Disease: San Diego Population Study,” Journal of Vascular Surgery 37 (2003): 1047–1053.
    1. N. A. Zakai, L. A. McClure, S. E. Judd, et al., “Racial and Regional Differences in Venous Thromboembolism in the United States in 3 Cohorts,” Circulation 129, no. 14 (2014): 1502–1509, https://doi.org/10.1161/CIRCULATIONAHA.113.006472.

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