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. 2025 Jun;22(2):467-469.
doi: 10.1007/s11673-024-10415-2. Epub 2025 Apr 30.

Genome Editing Should Preferably Be Carried Out on Fetuses In Utero Rather Than IVF Embryos

Alexis Heng Boon Chin  1 , Ningyu Sun  2 , Jiao Yang  3
Affiliations

Genome Editing Should Preferably Be Carried Out on Fetuses In Utero Rather Than IVF Embryos

Alexis Heng Boon Chin et al. J Bioeth Inq. 2025 Jun.
No abstract available

Keywords: Defect; Ethics; Fetal; Gene therapy; Monogenic disorders; Preimplantation embryo.

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Conflict of interest statement

Declarations. Ethical Declaration: No human subjects or laboratory animals were utilized. Conflict of Interests: None.

References

    1. Khan, S., and K. Drabiak. 2024. Eight strategies to engineer acceptance of human germline modifications. Journal of Bioethical Inquiry 21(1): 81–94. - PubMed
    1. Kubikova, N., M. Esbert, S. Titus, et al. 2023. Deficiency of DNA double-strand break repair in human preimplantation embryos revealed by CRISPR-Cas9. Human Reproduction 38(S1): dead093.089.
    1. Liang, P., Y. Xu, X. Zhang, et al. 2015. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & Cell 6(5): 363–372.
    1. Madero, J.I., M.C. Manotas, M. García-Acero, A. López Cáceres, and J.C. López. 2023. Preimplantation genetic testing in assisted reproduction. Minerva Obstetrics and Gynecology 75(3): 260–272. - PubMed
    1. Mattar, C.N.Z., M.K. Labude, T.N. Lee, and P.S. Lai. 2021. Ethical considerations of preconception and prenatal gene modification in the embryo and fetus. Human Reproduction 36(12): 3018–3027. - PubMed

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