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. 1985 Jul;38(7):840-8.
doi: 10.7164/antibiotics.38.840.

New antitumor antibiotics, FR-900405 and FR-900406. II. Production, isolation, characterization and antitumor activity

S Kiyoto, M Nishikawa, H Terano, M Kohsaka, H Aoki, H Imanaka, Y Kawai, I Uchida, M Hashimoto
Free article

New antitumor antibiotics, FR-900405 and FR-900406. II. Production, isolation, characterization and antitumor activity

S Kiyoto et al. J Antibiot (Tokyo). 1985 Jul.
Free article

Abstract

The new antitumor antibiotics, FR-900405 and FR-900406, were isolated from the culture broth of Actinomadura pulveracea sp. nov. No. 6049. These compounds which contain sulfur in the molecule, represent a novel class of antitumor agents. FR-900405 and FR-900406 are highly active in mice against experimental tumors and exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi.

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