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Editorial
. 2025 Sep 17;27(8):2088-2089.
doi: 10.1093/neuonc/noaf116.

Spatial transcriptomics: Advances and challenges in peripheral nerve sheath tumor

Affiliations
Editorial

Spatial transcriptomics: Advances and challenges in peripheral nerve sheath tumor

Zirong Huo et al. Neuro Oncol. .
No abstract available

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Conflict of interest statement

None declared.

Comment on

References

    1. Bremer J, Franco P, Menstell JA, et al. Spatially resolved transcriptomics of benign and malignant peripheral nerve sheath tumors. Neuro Oncol. 2025;23:27(8):2073–2087. - PMC - PubMed
    1. Amani V, Riemondy KA, Fu R, et al. Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas. Acta Neuropathol Commun. 2023;11(1):158. - PMC - PubMed
    1. Mitchell DK, Burgess B, White EE, et al. Spatial gene expression profiling unveils immuno-oncogenic programs of NF1-associated peripheral nerve sheath tumor progression. Clin Cancer Res. 2024;30(5):1038–1053. - PMC - PubMed
    1. Høland M, Berg KCG, Eilertsen IA, et al. Transcriptomic subtyping of malignant peripheral nerve sheath tumours highlights immune signatures, genomic profiles, patient survival and therapeutic targets. EBioMed. 2023;97:104829. - PMC - PubMed
    1. Somatilaka BN, Madana L, Sadek A, et al. STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy. J Clin Invest. 2024;134(10):e176748. - PMC - PubMed

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