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. 2025 May 1;392(17):1752-1759.
doi: 10.1056/NEJMsr2413289.

The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption

Susan M Gapstur  1 , Daniela Mariosa  1 , Luciana Neamtiu  1 , Suzanne T Nethan  1 , Jürgen Rehm  2 , Taisia Huckle  3 , David H Jernigan  4 , Elizabeth A O'Connor  5 , Mindaugas Štelemėkas  6 , Peter Allebeck  7 , Sawitri Assanangkornchai  8 , Nicholas Carah  9 , Surasak Chaiyasong  10 , Samantha Cukier  11 , The Son Dao  12 , Rijo M John  13 , Richard Matzopoulos  14   15 , Petra S Meier  16 , Paula O'Brien  17 , Guillermo Paraje  18 , Robin Room  19 , Claire Wilkinson  20 , Norman D Maldonado  21 , Tim Stockwell  22 , Maria Neufeld  23 , Dag Rekve  24 , Béatrice Lauby-Secretan  1
Affiliations

The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption

Susan M Gapstur et al. N Engl J Med. .
No abstract available

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Conflict of interest statement

Before and during their participation, all Working Group members were required to provide Declarations of Interest. Upon review by the International Agency for Research on Cancer, none of the interests declared by the Working Group members was considered to represent a potential or significant conflict of interest with respect to their activity for the work.

Figures

Figure 1.
Figure 1.. Schema for the development of IARC Handbooks Volumes 20A and 20B.
This figure is updated from IARC Handbooks Volume 20A. Panel A shows the two-step evaluative framework from which, for scientific reasons, the level of evidence that an intervention prevents cancer is established by way of an intermediate outcome, as described in the IARC Handbooks of Cancer Prevention Preamble for Primary Prevention. In this framework, the intermediate outcome is defined as a change in exposure (decrease in exposure to an established cancer risk factor or increase in exposure to a cancer-preventive factor). In Step 1, the effect of a specified intervention on the intermediate outcome is evaluated. In Step 2, the effect of the intermediate outcome on cancer incidence in humans is evaluated. If it has not yet been established in authoritative sources that the intermediate outcome reduces cancer incidence in humans, Step 2 is conducted before Step 1. Panel B shows the development of IARC Handbooks Volumes 20A and 20B. Because the evidence that reduction or cessation of alcohol consumption reduces cancer incidence in humans had not been evaluated before, such evidence was reviewed and evaluated first. Then, the evidence that selected population-level alcohol policy interventions reduce alcohol consumption was reviewed and evaluated (IARC Handbooks Volume 20B, in preparation).
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References

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