Corneal Neurotization: Paving the Path to Reinnervation

Abstract

Neurotrophic keratopathy (NK), a degenerative corneal disease characterized by the loss of innervation to the cornea, has historically required long-term supportive treatment with a poor prognosis for rehabilitation. Corneal neurotization restores corneal sensation, permanently addressing the underlying pathophysiology of NK. Surgical approaches to corneal neurotization are expanding and undergoing refinement as more centers perform this intervention. This article describes the indications, surgical approaches, outcomes, and future directions of corneal neurotization.

Keywords: Corneal neurotization; Direct neurotization; Indirect neurotization; Neurotrophic keratopathy.