Emerging nanostructure-based strategies for breast cancer therapy: innovations, challenges, and future directions

Abstract

Breast cancer, one of the leading causes of cancer-associated deaths, is responsible for the majority of cases of cancer in women globally. Traditional therapies used for the treatment of cancer have some challenges such as low cellular absorption, multidrug resistance, and limited bioavailability. Current innovations in nanotechnology, such as nanoliposomes, silver nanoparticles, gold nanoparticles, and carbon nanotubes, provide a promising approach to deal with these limitations. Nanostructures encapsulating anticancer agents such as doxorubicin, curcumin, paclitaxel, erlotinib, and docetaxel enhance the therapeutic efficacy of these agents and promote targeted drug delivery. Curcumin-loaded amorphous calcium carbonate nanoparticles encapsulating lipids and L-arginine exhibit higher cytotoxicity than free curcumin. Gold nanoparticles can also enhance treatment efficacy by specifically destroying tumor cells when used in photothermal therapy. This review focus on the abilities of nanoparticles to induce oxidative stress, prevent proliferation, and trigger apoptosis in cancer cells. Further research should focus on optimizing these nanoparticles to enhance the targeted drug delivery and address multi-drug resistance. Our review underscores recent developments in nanostructures, their therapeutic potential, and the challenges that need to be addressed for more effective breast cancer treatment.

Keywords: Breast cancer; Carbon nanotubes; Combat multidrug resistance; Gold nanoparticles; Nanoliposomal formulations; Silver nanoparticles.