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Review
. 2025 Jul 1;53(3):101-109.
doi: 10.1249/JES.0000000000000364. Epub 2025 May 1.

Novel Insights to Mitochondrial Impact in Aging Skeletal Muscle

Maya Semel  1 , Cole Lukasiewicz  2 , Russell T Hepple
Affiliations
Review

Novel Insights to Mitochondrial Impact in Aging Skeletal Muscle

Maya Semel et al. Exerc Sport Sci Rev. .

Abstract

Our Perspective for Progress highlights sex differences in skeletal muscle mitochondrial function that evolve with aging, with an influence of denervation emerging in advanced age. Gaps include knowledge about mitochondrial alterations in microdomains of muscle fibers, plasticity of the mitochondrial reticulum to acute muscle contractions, and advanced age of both sexes.

Keywords: aging; denervation; heterogeneity; mitochondria; skeletal muscle.

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