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. 2025 Apr 29;8(5):e70775.
doi: 10.1002/hsr2.70775. eCollection 2025 May.

Replenish Revenue by Low-Cost Medicines, an Institution-Specific Action to Improve Access to High-Cost Medicines Used for Chronic Illness in Ethiopia: Narrative Review

Mende Mensa Sorato  1   2
Affiliations

Replenish Revenue by Low-Cost Medicines, an Institution-Specific Action to Improve Access to High-Cost Medicines Used for Chronic Illness in Ethiopia: Narrative Review

Mende Mensa Sorato. Health Sci Rep. .

Abstract

Background: Over one-quarter of the global population has no access to essential medicines. Improving access to medicines for chronic illness requires multi-level interventions. Nearly half of the people who need insulin cannot afford it.

Aim: To describe institution-specific interventions that can be applied to improve access to high-cost medicines used for chronic diseases without affecting revenue generated from pharmaceuticals.

Methods: A narrative review was conducted by using articles written in the English language from January 2000 to May 2020 and retrieved from PubMed/Medline, Embase, Cochrane Library, Scopus, Web of Science, and Google Scholar with the following systematic search query.

Results: Fifty-three studies were included. Most of the drugs used for the treatment of hypertension, diabetes, chronic asthma, and cancer are not available in adequate quantity. It requires more than 4 months' wage for a lowest-paid worker to buy one cycle of treatment for non-Hodgkin lymphoma, cervical cancer, or breast cancer in Ethiopia. The replenish revenue by low-cost medicines (RRLCM) model theoretically improved access to high-cost medicines. This model's steps include: (1) Estimate the number of patients who will take high-cost medicine for specific chronic diseases. (2) Estimate the amount of high-cost medicine required in a given period. (3) Calculate the markup-related change in revenue. (4) Select fast-moving items with better affordability in the supply chain. (5) Estimate revenue by modifying the markup of fast-moving items with better public affordability, and (6) calculate the difference and compare the markup-related revenue resulting from adjusting markups.

Conclusion: Medicines used for chronic diseases are neither available nor affordable. The RRLCM model has potential to improve affordability, pending empirical validation. Therefore, it is important to reform national drug policy in light of pricing and markup regulation system. Researchers, who are willing to work in the similar area should evaluate the applicability of RRLCM model in different set-ups.

Keywords: access to high‐cost medicines; facility‐specific regressive markup; non‐communicable diseases; pharmaceutical price regulation; replenish revenue by low‐cost medicines.

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Conflict of interest statement

The author declares no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart representing the selection of sources of evidence and the number of articles excluded and eligible for review.
Figure 2
Figure 2
Conceptual Framework showing the relationship between the price of medicines on the access to essential medicines and treatment outcomes of patients with chronic diseases, adapted from different literature. The arrows do not include the explicit list of interactions but show the important link between high medicine prices and reduced access to essential medicines.
Figure 3
Figure 3
Markup system and regulation in Ethiopia. EPSS, Ethiopian Pharmaceutical Supply Service. Source: Author.
Figure 4
Figure 4
Replenish Revenue by Low‐Cost Medicines (RRLCM) Theoretical model showing strategies to improve affordability of high‐cost medicines. Source: Author.
See this image and copyright information in PMC

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