Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross-Sectional Study
- PMID: 40309633
- PMCID: PMC12040726
- DOI: 10.1002/hsr2.70773
Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross-Sectional Study
Abstract
Background and aims: Sickle Cell Disease is a chronic inflammatory disease that could be aggravated by exposure to variable factors such as infections, hemolysis, oxidative stress and so forth. that could preciptate variable acute or end-organ manifestation. However, the degree of inflammation could vary in individuals. Thus this study evaluates the inflammatory state (hs-CRP, IL6, ferritin) of children living with SCD and the associated factors.
Methods: We conducted an analytical cross-sectional study for 03 months. The patients included were those from the Central Hospital of Yaounde and the Regional Hospital of Bafoussam in which they are regularly monitored and/or interned in the Hematology department. The exploration of inflammation was made by determining hs-CRP, IL6, and ferritin concentrations. The hematological parameters and iron profile were evaluated using standard methods. Statistical analyses of the data were carried out using the statistical software R version 4.1.1. from which logistic regression analyses according to univariate and multivariate models made it possible to identify factors associated with inflammation in patients.
Results: Hundred and forty-nine SCD patients were included in the study. The frequency of inflammation in the population was 42.3%. Hyperferritinemia was significantly greater (p < 0.001) in patients with inflammation compared to the noninflammatory patients (96.8% and 76.7% respectively). Patients with inflammation showed a significant elevation of iron parameters (p < 0.05). In addition, ferritin and IL6 elevation were associated with inflammation during sickle cell disease, respectively (OR = 4.96; 95% CI [1.15-36.42]; p = 0.056) and (OR = 6.23; 95% CI [1.43-45.96]; p = 0.030).
Conclusion: The elevated iron in plasma is an effect of inflammation in sickle cell patients. Thus, inflammation constitutes a significant and significant factor in worsening the pathophysiology of sickle cell disease. Hence the need of controlling inflammation and iron in the latter is necessary.
Keywords: associated factors; inflammation; iron profile; sickle cell anemia.
© 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
References
-
- Nkashama G. M., Wakamb G. K. A., Mulangu A. M., Nkashama G. M., Kupa B. K., and Numbi O. L., “De L'hémoglobine Ss À SF: Intérêt De L'hydroxyurée Dans La Prise En Charge De La Drépanocytose Chez 2 Enfants Congolais Et Revue De La Literature,” Pan African Medical Journal 21 (2015): 1317–1322. - PMC - PubMed
-
- Al‐Saqladi A. W. M., Bin‐Gadeem H. A., and Brabin B. J., “Utility of Plasma Transferrin Receptor, Ferritin and Inflammatory Markers in Children With Sickle Cell Disease,” Paediatrics and International Child Health 32 (2012): 27–34. - PubMed
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous