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. 2025 Apr 29;8(5):e70773.
doi: 10.1002/hsr2.70773. eCollection 2025 May.

Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross-Sectional Study

Romaric De Manfouo Tuono  1   2   3 , Josué Louokdom Simo  2 , Prosper Cabral Biapa Nya  4   5 , Claude Tagny Tayou  3 , Constant Anatole Pieme  6
Affiliations

Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross-Sectional Study

Romaric De Manfouo Tuono et al. Health Sci Rep. .

Abstract

Background and aims: Sickle Cell Disease is a chronic inflammatory disease that could be aggravated by exposure to variable factors such as infections, hemolysis, oxidative stress and so forth. that could preciptate variable acute or end-organ manifestation. However, the degree of inflammation could vary in individuals. Thus this study evaluates the inflammatory state (hs-CRP, IL6, ferritin) of children living with SCD and the associated factors.

Methods: We conducted an analytical cross-sectional study for 03 months. The patients included were those from the Central Hospital of Yaounde and the Regional Hospital of Bafoussam in which they are regularly monitored and/or interned in the Hematology department. The exploration of inflammation was made by determining hs-CRP, IL6, and ferritin concentrations. The hematological parameters and iron profile were evaluated using standard methods. Statistical analyses of the data were carried out using the statistical software R version 4.1.1. from which logistic regression analyses according to univariate and multivariate models made it possible to identify factors associated with inflammation in patients.

Results: Hundred and forty-nine SCD patients were included in the study. The frequency of inflammation in the population was 42.3%. Hyperferritinemia was significantly greater (p < 0.001) in patients with inflammation compared to the noninflammatory patients (96.8% and 76.7% respectively). Patients with inflammation showed a significant elevation of iron parameters (p < 0.05). In addition, ferritin and IL6 elevation were associated with inflammation during sickle cell disease, respectively (OR = 4.96; 95% CI [1.15-36.42]; p = 0.056) and (OR = 6.23; 95% CI [1.43-45.96]; p = 0.030).

Conclusion: The elevated iron in plasma is an effect of inflammation in sickle cell patients. Thus, inflammation constitutes a significant and significant factor in worsening the pathophysiology of sickle cell disease. Hence the need of controlling inflammation and iron in the latter is necessary.

Keywords: associated factors; inflammation; iron profile; sickle cell anemia.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Prevalence of inflammation in the population.
See this image and copyright information in PMC

References

    1. Meher S., Mohanty P. K., Patel S., et al., “Haptoglobin Genotypes Associated With Vaso‐Occlusive Crisis in Sickle Cell Anemia Patients of Eastern India,” Hemoglobin 45 (2021): 358–364, 10.1080/03630269.2020.1801459. - DOI - PubMed
    1. Nkashama G. M., Wakamb G. K. A., Mulangu A. M., Nkashama G. M., Kupa B. K., and Numbi O. L., “De L'hémoglobine Ss À SF: Intérêt De L'hydroxyurée Dans La Prise En Charge De La Drépanocytose Chez 2 Enfants Congolais Et Revue De La Literature,” Pan African Medical Journal 21 (2015): 1317–1322. - PMC - PubMed
    1. Frömmel C., “Newborn Screening for Sickle Cell Disease and Other Hemoglobinopathies: A Short Review on Classical Laboratory Methods—Isoelectric Focusing, HPLC, and Capillary Electrophoresis,” International Journal of Neonatal Screening 4 (2018): 39. - PMC - PubMed
    1. Jana S., Strader M. B., Meng F., et al., “Hemoglobin Oxidation‐Dependent Reactions Promote Interactions With Band 3 and Oxidative Changes in Sickle Cell‐Derived Microparticle,” Journal of Clinical Investigation Insight 3 (2018): 1–20. - PMC - PubMed
    1. Al‐Saqladi A. W. M., Bin‐Gadeem H. A., and Brabin B. J., “Utility of Plasma Transferrin Receptor, Ferritin and Inflammatory Markers in Children With Sickle Cell Disease,” Paediatrics and International Child Health 32 (2012): 27–34. - PubMed

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