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Review
. 2025 Mar 21;15(4):68.
doi: 10.3390/clinpract15040068.

The Effect of Pregnancy on Dermatological Disorders: A Systematic Review

Maya Faissal Alhomieed  1 , Lara Osama Al Hartany  1 , Marya Aref Alghorab  1 , Arwa Alsharif  1 , Ahlam Kaleemullah  1 , Hanan Ismail Wasaya  1 , Khlood Abdulaziz Alsubaie  1 , Ayah Nabil Al Jehani  1 , Amal Mohamed Kayali  1 , Samera AlBasri  2
Affiliations
Review

The Effect of Pregnancy on Dermatological Disorders: A Systematic Review

Maya Faissal Alhomieed et al. Clin Pract. .

Abstract

Background: Pregnancy induces hormonal, immunologic, and vascular changes that profoundly affect dermatologic health. This systematic review aimed to assess the impact of pregnancy on dermatological disorders in terms of disease incidence, severity, maternal-fetal outcomes, and optimal management strategies. Methods: A systematic search was performed in PubMed, MEDLINE, and Web of Science databases, following PRISMA guidelines. Studies evaluating pregnant women with dermatological disorders, pregnancy-related dermatoses, and pre-existing morbidities, were included. The collaboratively extracted data included patient demographics, disease severity, treatment approaches, and pregnancy outcomes. Results: A total of 8490 pregnant cases with dermatologic changes and conditions caused by pregnancy were studied. The dermatological conditions were divided into physiological changes, pregnancy-related exacerbation of pre-existing skin conditions, and pregnancy-specific dermatoses. Intrahepatic cholestasis of pregnancy and pemphigoid gestationis were associated with increased rates of adverse fetal outcomes in patients with specific dermatoses, including increased preterm birth and fetal distress rates. The atopic eruption of pregnancy and polymorphic eruption of pregnancy were highly relevant, but their effect on fetal health was minimal. The efficacy and safety of treatment modalities, including corticosteroids, antihistamines, and ursodeoxycholic acid, were variable. Conclusions: Pregnancy drastically affects dermatological health, but the nature of the impact depends on the condition. Optimal maternal and fetal outcomes rely on early diagnosis and individualized management strategies. More randomized controlled trials are required to develop standardized diagnostic and treatment guidelines to enhance the quality of dermatologic care during pregnancy.

Keywords: atopic eruption of pregnancy (AEP); dermatology in pregnancy; intrahepatic cholestasis (ICP); maternal health; pemphigoid gestationis (PG); polymorphic eruption of pregnancy (PEP); pregnancy dermatoses; skin disorder.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
The phases of the study’s selection procedure in a comprehensive PRISMA chart utilized for the systematic review.
Figure 2
Figure 2
Overview of treatment approaches for pregnancy-related dermatological disorders.
See this image and copyright information in PMC

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References

    1. Panicker V.V., Riyaz N., Balachandran P. A clinical study of cutaneous changes in pregnancy. J. Epidemiol. Glob. Health. 2016;7:63–70. doi: 10.1016/j.jegh.2016.10.002. - DOI - PMC - PubMed
    1. Vora R.V., Gupta R., Mehta M.J., Chaudhari A.H., Pilani A.P., Patel N. Pregnancy and skin. J. Fam. Med. Prim. Care. 2014;3:318–324. doi: 10.4103/2249-4863.148099. - DOI - PMC - PubMed
    1. Gupta S.N., Madke B., Ganjre S., Jawade S., Kondalkar A. Cutaneous changes during pregnancy: A comprehensive review. Cureus. 2024;16:e69986. doi: 10.7759/cureus.69986. - DOI - PMC - PubMed
    1. Vk S., Wf S. Dermatoses of pregnancy. [(accessed on 13 January 2025)];Am. Fam. Physician. 1988 37:131–138. Available online: https://pubmed.ncbi.nlm.nih.gov/3276095. - PubMed
    1. Kepley J.M., Bates K., Mohiuddin S.S. Physiology, Maternal Changes. StatPearls; Treasure Island, FL, USA: 2019. [(accessed on 13 January 2025)]. Available online: https://europepmc.org/article/MED/30969588. - PubMed

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