A fungal ally wards off liver disease

Lora V Hooper^{1

2

3}, Andrew Y Koh^{2

4

5}

Affiliations

¹ Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
² Department of Microbiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
³ The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
⁴ Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
⁵ Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

PMID: 40310928
DOI: 10.1126/science.adx1789

Comment

A fungal ally wards off liver disease

Lora V Hooper et al. Science. 2025 May.

. 2025 May;388(6746):470-471.

doi: 10.1126/science.adx1789. Epub 2025 May 1.

Authors

Lora V Hooper^{1

2

3}, Andrew Y Koh^{2

4

5}

Affiliations

¹ Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
² Department of Microbiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
³ The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
⁴ Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
⁵ Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

PMID: 40310928
DOI: 10.1126/science.adx1789

Abstract

A metabolite secreted by an intestinal fungus blunts metabolic disease.

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Comment on

A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis.
Zhou S, Li M, Wang P, Guo C, Zhang J, Luo X, Fan YC, Chen EQ, Qi X, Chen J, Ye L, Yuan HY, Yin WB, Wang K, Zheng MH, Pang Y, Qiao J, Jiang C. Zhou S, et al. Science. 2025 May;388(6746):eadp5540. doi: 10.1126/science.adp5540. Epub 2025 May 1. Science. 2025. PMID: 40310917

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A fungal ally wards off liver disease

Affiliations

A fungal ally wards off liver disease

Authors

Affiliations

Abstract

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Supplementary concepts

LinkOut - more resources

Full Text Sources

Medical