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Comment
. 2025 May;388(6746):468-469.
doi: 10.1126/science.adx1186. Epub 2025 May 1.

Searching for partners

Yuwei Zhong  1 , Claude Desplan  1
Affiliations
Comment

Searching for partners

Yuwei Zhong et al. Science. 2025 May.

Abstract

Simplifying a three-dimensional search helps neurons find their targets.

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Figures

Figure:
Figure:
Making the right connections During development of the fruit fly olfactory system, olfactory receptor neurons (ORNs) project from the antenna to the antennal lobe. There they must find the dendrites of specific projection neurons, which extend their dendrites into the antennal lobe to form preglomerular structures at stereotypic positions. A simplified search Projection neurons in both interior and exterior glomeruli extend some dendrites to the surface of the antennal lobe. They act as beacons and are recognized by their partner ORNs as they follow a predetermined trajectory across the lobe surface and continue to the contralateral antennal lobe.
Figure:
Figure:
Making the right connections During development of the fruit fly olfactory system, olfactory receptor neurons (ORNs) project from the antenna to the antennal lobe. There they must find the dendrites of specific projection neurons, which extend their dendrites into the antennal lobe to form preglomerular structures at stereotypic positions. A simplified search Projection neurons in both interior and exterior glomeruli extend some dendrites to the surface of the antennal lobe. They act as beacons and are recognized by their partner ORNs as they follow a predetermined trajectory across the lobe surface and continue to the contralateral antennal lobe.
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References

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