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Observational Study
. 2025 May 1;29(1):172.
doi: 10.1186/s13054-025-05409-4.

Lack of preload responsiveness may determine poor clinical outcomes in mechanically ventilated patients with ARDS

Sebastien Preau  1   2 , Olivier Pouly  3   4 , Mehdi Ederkaoui  3   5 , Arthur Durand  3 , Claire Bourel  3 , Thierry Onimus  3 , Laurine Cadart  3 , Julien Labreuche  3 , Michael Howsam  6 , Raphaël Favory  3   6 , Alexandre Pierre  3   6
Affiliations
Observational Study

Lack of preload responsiveness may determine poor clinical outcomes in mechanically ventilated patients with ARDS

Sebastien Preau et al. Crit Care. .

Abstract

NCT03763773 . Registered 3 December 2018.

Keywords: ARDS; Acute respiratory distress syndrome; Fluid responsiveness; Intensive care; Mechanical ventilation; Preload responsiveness; Prognosis; Superior vena cava; Transesophageal echocardiography.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study received approval from the Northwest ethics committee (protocol number 2018 A014 63 52). Each inclusion required oral and written informed consent from a representative (spouse, close relative, or friend) and then from the patient as soon as they were able to provide it. Consent for publication: Not applicable. Competing interests: The authors declare that they have no conflict of interest. SP has received payments from AOP Orphan and Viatris for lectures.

Figures

Fig. 1
Fig. 1
Associations between cSVC and outcomes. Scatterplot of cSVC-mean value and the number of days without mechanical ventilation at day 28 (A). Areas under the receiver operating characteristics (ROC) curve for predicting 28 day-mortality with cSVC-mean, cSVC-d1 and cSVC-d3 (B). cSVC, collapsibility index of the superior vena cava; cSVC-d1 and d3, cSVC value on day-1 and day-3; cSVC-mean, average cSVC over the monitoring duration (maximum of 3 days)
See this image and copyright information in PMC

References

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Associated data

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