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. 2025 May;66(3):281-283.
doi: 10.4111/icu.20250030.

Accounting for the learning curve effect in surgical trials: Post-hoc analysis of the prophylactic use of biologic mesh in ileal conduit (PUBMIC) trial

Alireza Ghoreifi  1 , Rashid K Sayyid  1 , Farshad Sheybaee Moghaddam  1 , Hooman Djaladat  2
Affiliations

Accounting for the learning curve effect in surgical trials: Post-hoc analysis of the prophylactic use of biologic mesh in ileal conduit (PUBMIC) trial

Alireza Ghoreifi et al. Investig Clin Urol. 2025 May.

Abstract

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Conflict of interest statement

The authors have nothing to disclose.

Figures

Fig. 1
Fig. 1. Two-year incidence rates of radiologic parastomal hernias (PSHs), clinical PSH, and undergoing surgery for PSH repair.
Fig. 2
Fig. 2. Two-year incidence rates of overall, high-grade, wound, and infectious complications and readmissions.
See this image and copyright information in PMC

References

    1. Corrigan N, Brown JM, Emsley R, Jayne DG, Walwyn REA. Surgical trial design for incorporating the effects of learning: what is the current methodological guidance, and is it sufficient? Trials. 2023;24:294. - PMC - PubMed
    1. Wallis CJD, Detsky AS, Fan E. Establishing the effectiveness of procedural interventions: the limited role of randomized trials. JAMA. 2018;320:2421–2422. - PubMed
    1. Djaladat H, Ghoreifi A, Tejura T, Miranda G, Cai J, Sheybaee Moghaddam F, et al. Prophylactic use of biologic mesh in ileal conduit (PUBMIC): a randomized clinical trial. J Urol. 2024;211:743–753. - PubMed

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