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. 2025 Apr 29;6(5):e70022.
doi: 10.1002/bco2.70022. eCollection 2025 May.

Association of overactive bladder with all-cause and cardiovascular mortality in women: A propensity-matched NHANES study

Weipu Mao  1 , Sagar Barge  1 , Zhaobo Luo  1 , Weiqun Yu  1
Affiliations

Association of overactive bladder with all-cause and cardiovascular mortality in women: A propensity-matched NHANES study

Weipu Mao et al. BJUI Compass. .

Abstract

Objectives: To examine the impact of overactive bladder (OAB) on all-cause and cardiovascular mortality in women in a real-world setting, and to examine the association of TyG-related indices with OAB.

Methods: Data on 6580 women aged ≥20 years were collected from the National Health and Nutrition Examination Survey (NHANES) database. Kaplan-Meier curves and Cox survival analysis were used to evaluate the association between OAB and all-cause and cardiovascular mortality. Biomarkers for metabolic syndrome were assessed for their association with OAB, including triglyceride-glucose (TyG) and TyG-related indices. The association between TyG-related indices and OAB was evaluated using restricted cubic splines (RCS), receiver operating characteristic (ROC) curves and multivariate logistic regression, with propensity score matching (PSM) employed to balance confounders between OAB and non-OAB groups.

Results: Kaplan-Meier curves showed that OAB was associated with a poorer prognosis, and multivariate Cox regression analyses indicated that OAB was an independent risk factor for both all-cause and cardiovascular mortality. RCS revealed a positive association between TyG-related indices and OAB. Both ROC curves and multivariate logistic regression analysis indicated that TyG-WHtR (TyG combined with waist-to-height ratio) was strongly associated with OAB, with a higher TyG-WHtR associated with an increased risk of OAB. The retrospective design and selection bias may be the potential limitations.

Conclusions: OAB is positively associated with all-cause and cardiovascular mortality in women. TyG-related indices are positively associated with OAB, with TyG-WHtR as the most effective index.

Keywords: all‐cause mortality; cardiovascular mortality; overactive bladder; propensity score matching; triglyceride‐glucose index.

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Conflict of interest statement

We declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
All‐cause and cardiovascular mortality curves between the overactive bladder and the non‐overactive bladder group after 1:1 propensity score matching (PSM). (A) All‐cause mortality curves; (B) cardiovascular mortality curves.
FIGURE 2
FIGURE 2
Forest plots of different models of multivariate cox regression analysis of the relation between OAB and all‐cause and cardiovascular deaths in women after 1:1 propensity score matching (PSM). (A) All‐cause mortality; (B) cardiovascular mortality.
FIGURE 3
FIGURE 3
The dose–response analysis between TyG‐related indices and overactive bladder occurrence before propensity score matching (PSM). (A) BMI; (B) WC; (C) TyG; (D) TyG‐BMI; (E) TyG‐WC; (F) TyG‐WHtR. SD = standard deviation; CI = confidence interval.
See this image and copyright information in PMC

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