From Repurposing to Refinement: Optimizing Levofloxacin for Treatment of Multidrug-Resistant Tuberculosis

Affiliations

Editorial

Jae-Joon Yim. Am J Respir Crit Care Med. 2025 Jul.

. 2025 Jul;211(7):1126-1127.

doi: 10.1164/rccm.202503-0550ED.

¹ Department of Internal Medicine Seoul National University College of Medicine Seoul, Republic of Korea.

No abstract available

Comment on

Efficacy and Safety of Higher Doses of Levofloxacin for Multidrug-resistant Tuberculosis: A Randomized, Placebo-controlled Phase II Clinical Trial.
Phillips PPJ, Peloquin CA, Sterling TR, Kaur P, Diacon AH, Gotuzzo E, Benator D, Warren RM, Sikes D, Lecca L, Gandhi NR, Streicher EM, Dianis N, Eisenach K, Mitnick CD, Horsburgh CR Jr. Phillips PPJ, et al. Am J Respir Crit Care Med. 2025 Jul;211(7):1277-1287. doi: 10.1164/rccm.202407-1354OC. Am J Respir Crit Care Med. 2025. PMID: 40080768 Free PMC article. Clinical Trial.

1. Wong EB, Cohen KA, Bishai WR. Rising to the challenge: new therapies for tuberculosis. Trends Microbiol . 2013;21:493–501. - PMC - PubMed
1. Yoon YS, Lee HJ, Yoon HI, Yoo CG, Kim YW, Han SK. et al. Impact of fluoroquinolones on the diagnosis of pulmonary tuberculosis initially treated as bacterial pneumonia. Int J Tuberc Lung Dis . 2005;9:1215–1219. - PubMed
1. Seifert M, Georghiou SB, Garfein RS, Catanzaro D, Rodwell TC. Impact of fluoroquinolone use on mortality among a cohort of patients with suspected drug-resistant tuberculosis. Clin Infect Dis . 2017;65:772–778. - PMC - PubMed
1. Chan ED, Laurel V, Strand MJ, Chan JF, Huynh ML, Goble M. et al. Treatment and outcome analysis of 205 patients with multidrug-resistant tuberculosis. Am J Respir Crit Care Med . 2004;169:1103–1109. - PubMed
1. Ahmad N, Ahuja SD, Akkerman OW, Alffenaar J-WC, Anderson LF, Baghaei P. et al. Collaborative Group for the Meta-Analysis of Individual Patient Data in MDRTB. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet . 2018;392:821–834. - PMC - PubMed