Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens
- PMID: 403152
Item in Clipboard
Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens
Invest Ophthalmol Vis Sci.
1977 Mar.
Abstract
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) make up the sorbitol pathway, which has been implicated in the pathogenesis of sugar cataracts. The levels of the two enzymes were determined with quantitative histochemical techniques in the epithelium, cortex, and nucleus of normal and diabetic rat lenses. The ratio of activity of AR to SDH was found to be nearly 50 to 1 in all substructures. This would strongly favor sorbitol accumulation and subsequent cataract formation.
Similar articles
-
Aldose reductase and sorbitol dehydrogenase distribution in rat kidney.J Histochem Cytochem. 1977 Jan;25(1):1-8. doi: 10.1177/25.1.401844. J Histochem Cytochem. 1977. PMID: 401844
-
The sorbitol pathway in the human lens: aldose reductase and polyol dehydrogenase.Invest Ophthalmol Vis Sci. 1981 Mar;20(3):314-26. Invest Ophthalmol Vis Sci. 1981. PMID: 6782033
-
Biochemical and morphological changes during development of sugar cataract in Otsuka Long-Evans Tokushima fatty (OLETF) rat.Exp Eye Res. 2001 Sep;73(3):375-81. doi: 10.1006/exer.2001.1046. Exp Eye Res. 2001. PMID: 11520112
-
[The role of polyol pathways in formation of diabetic cataracts].Klin Oczna. 1997;99(6):401-4. Klin Oczna. 1997. PMID: 9685789 Review. Polish.
-
[Sorbitol route of glucose metabolism and complication of diabetes mellitus].Probl Endokrinol (Mosk). 1980 May-Jun;26(3):86-90. Probl Endokrinol (Mosk). 1980. PMID: 6773043 Review. Russian. No abstract available.
Cited by
-
Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl.Proc Natl Acad Sci U S A. 1987 Mar;84(6):1718-20. doi: 10.1073/pnas.84.6.1718. Proc Natl Acad Sci U S A. 1987. PMID: 3104902 Free PMC article.
-
Exosomal miR-29b found in aqueous humour mediates calcium signaling in diabetic patients with cataract.Int J Ophthalmol. 2021 Oct 18;14(10):1484-1491. doi: 10.18240/ijo.2021.10.03. eCollection 2021. Int J Ophthalmol. 2021. PMID: 34667723 Free PMC article.
-
Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds.Biomed Res Int. 2017;2017:7375615. doi: 10.1155/2017/7375615. Epub 2017 Apr 23. Biomed Res Int. 2017. PMID: 28512639 Free PMC article.
-
Status of higher TGF-β1 and TGF-β2 levels in the aqueous humour of patients with diabetes and cataracts.BMC Ophthalmol. 2022 Apr 5;22(1):156. doi: 10.1186/s12886-022-02317-x. BMC Ophthalmol. 2022. PMID: 35379202 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
