The three calmodulin genes: territories defined?

Affiliations

Editorial

Marcos Gonzalez et al. Cardiovasc Res. 2025.

. 2025 Jul 8;121(7):977-979.

doi: 10.1093/cvr/cvaf075.

¹ Department of Physiology & Pharmacology, Des Moines University Medicine and Health Sciences, 8025, Grand Avenue, West Des Moines, IA 50266, USA.

No abstract available

Conflict of interest statement

Conflict of interest: none declared.

Distinct intracellular spatiotemporal expression of Calmodulin genes underlies functional diversity of Calmodulin-dependent signalling in cardiac myocytes.
Bogdanov V, Mariangelo JIE, Soltisz AM, Sakuta G, Pokrass A, Beard C, Orengo BH, Kalinin R, Ulker A, Yunker B, Tikunova S, Thuma J, Xu X, Hund TJ, Veeraraghavan R, Davis JP, Györke S. Bogdanov V, et al. Cardiovasc Res. 2025 Jul 8;121(7):1052-1065. doi: 10.1093/cvr/cvaf059. Cardiovasc Res. 2025. PMID: 40273382

1. Fischer R, Koller M, Flura M, Mathews S, Strehler-Page MA, Krebs J, Penniston JT, Carafoli E, Strehler EE. Multiple divergent mRNAs code for a single human calmodulin. J Biol Chem 1988;263:17055–17062. - PubMed
1. Shen X, Valencia CA, Szostak JW, Dong B, Liu R. Scanning the human proteome for calmodulin-binding proteins. Proc Natl Acad Sci U S A 2005;102:5969–5974. - PMC - PubMed
1. Tran QK, Black DJ, Persechini A. Intracellular coupling via limiting calmodulin. J Biol Chem 2003;278:24247–24250. - PubMed
1. Wu X, Bers DM. Free and bound intracellular calmodulin measurements in cardiac myocytes. Cell Calcium 2007;41:353–364. - PMC - PubMed
1. Toutenhoofd SL, Strehler EE. The calmodulin multigene family as a unique case of genetic redundancy: multiple levels of regulation to provide spatial and temporal control of calmodulin pools? Cell Calcium 2000;28:83–96. - PubMed