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. 2025 Nov:289:1-5.
doi: 10.1016/j.ahj.2025.04.024. Epub 2025 Apr 30.

Win ratio analysis of the LANDMARK trial

Akihiro Tobe  1 , Niels van Royen  2 , Ignacio J Amat-Santos  3 , Martin Hudec  4 , Matjaz Bunc  5 , Alexander Ijsselmuiden  6 , Jose Luis Pomar  7 , Liesbeth Rosseel  8 , Amr Gamal  9 , Javaid Iqbal  10 , Alan Soo  11 , Angela McInerney  12 , Scot Garg  13 , Udita Chandra  14 , Ashokkumar Thakkar  14 , Osama Soliman  1 , Yoshinobu Onuma  1 , Andreas Baumbach  15 , Patrick W Serruys  16
Affiliations
Free article

Win ratio analysis of the LANDMARK trial

Akihiro Tobe et al. Am Heart J. 2025 Nov.
Free article

Abstract

The LANDMARK trial reported the non-inferiority of the Myval transcatheter heart valve (THV) series compared with the contemporary standard THV series (Sapien and Evolut) for a 30-day composite endpoint in patients with severe aortic stenosis. This exploratory study compared the performance of the Myval THV series with the contemporary THV series using the win ratio analysis.

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Conflict of interest statement

Declaration of competing interest Niels van Royen reports research grants from Abbot, Philips, Medtronic and Biotronik. Niels van Royen reports speaker fees from RainMed, Microport, Bayer and Abbot. Ignacio J Amat-Santos reports consulting fees from Medtronic, Abbott, Boston Scientific, Meril Life Sciences and Products & Features. Matjaz Bunc reports lecture fees from Meril Life Sciences, Edwards Lifesciences and Medtronic. Matjaz Bunc is a president of the working group for interventional cardiology, cardiology society of Slovenia. Alexander Ijsselmuiden reports institutional fees from Medtronic and Abbott, and consulting fees from Meril Life Sciences, Cardiawave, Angiocare, Abbott, Philips, Svelte and Pulsecath. Angela McInerney reports a consulting fee from Medtronic, and payment or honoraria for lectures from Medtronic, Abbot Vascular, Shockwave medical and Boston Scientific. Scot Garg reports consulting fees from Biosensors. Udita Chandra and Ashokkumar Thakkar are employees of Meril Life Sciences. Osama Soliman reports an institutional research grant from Meril Life Sciences. Andreas Baumbach reports consulting fees from Faraday Pharma, PiCardia and Meril Life Sciences. Andreas Baumbach is a member of data safety monitoring board of PiCardia. Patrick W Serruys reports consultancy fees from SMT, Novartis, Meril Life Sciences, Xeltis, and Philips. All other authors declare no competing interests.

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