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. 2025 May;93(5):e70081.
doi: 10.1111/aji.70081.

Study on MTHFR (C677T & A1298C) Gene Polymorphisms in the Condition of Glucose Intolerance During Pregnancy

Bunga Papa Kusuma  1 , D Lakshmi Lalitha  2 , Nagarjuna Sivaraj  1 , Vijaya Sirisha Balaga  3 , Arun Kumar Rao Panchanani  4 , L V Simhachalam Kutikuppala  5 , S Sai Roshan  4 , K Kavya  4 , Golla Varshitha  6
Affiliations

Study on MTHFR (C677T & A1298C) Gene Polymorphisms in the Condition of Glucose Intolerance During Pregnancy

Bunga Papa Kusuma et al. Am J Reprod Immunol. 2025 May.

Abstract

Introduction: Gestational diabetes mellitus (GDM) is a prevalent medical complication in pregnancy, characterized by glucose intolerance. The global expected prevalence of GDM is approximately 15.1%. This study builds upon previous research by investigating elevated hematological parameters and exploring MTHFR gene polymorphisms in GDM.

Materials and methods: This study included 304 pregnant women, comprising 152 patients with GDM and an equal number of normal pregnant women. Employing PCR-RFLP techniques, we identified MTHFR gene polymorphisms (C677T & A1298C) associated with gestational diabetes.

Results: Significant associations were found in gestational age and platelet count, indicating their relevance to GDM risk. The odds ratios for both MTHFR A1298C (p value: 0.034; OR = 0.7; 95% CI: 0.5021-0.9758) and MTHFR C677T (p value: 0.008; OR = 0.5453; 95% CI: 0.3292-0.9011) gene polymorphisms demonstrated an increased risk of GDM development.

Conclusion: The study reveals that elevated platelet count and polymorphs increase the risk of developing GDM in pregnant women. Gestational age also plays a role. The study also finds a link between the MTHFR C677T SNP and the MTHFR A1298C gene polymorphism and the risk of gestational diabetes in Andhra Pradesh. This gives us new information about genetic and hematological factors.

Keywords: gene polymorphisms; gestational diabetes mellitus; glucose intolerance; pregnancy.

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