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. 1985 May-Jun;48(3):440-5.
doi: 10.1021/np50039a012.

Antineoplastic and piscicidal 1-alkyldaphnane orthoesters from Pimelea species

M I Tyler, M E Howden

Antineoplastic and piscicidal 1-alkyldaphnane orthoesters from Pimelea species

M I Tyler et al. J Nat Prod. 1985 May-Jun.

Abstract

Five biologically active daphnane orthoesters have been isolated from Pimelea species (Thymelaeaceae). Four of these possessing antineoplastic activity against in vivo murine P-388 lymphocytic leukemia are gnidimacrin from P. ligustrina, simpleximacrin from P. simplex, linimacrin d and Pimelea factor P3 from P. linifolia. Linimacrin c from P. linifolia and the other four compounds showed piscicidal activity. Gnidimacrin and Pimelea factor P3 have previously been isolated from other members of the Thymelaeaceae. Simpleximacrin and linimacrins c and d are new compounds.

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