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Published Erratum
. 2025 May 1;110(5):1238-1241.
doi: 10.3324/haematol.2024.286500. Epub 2025 May 1.

Erratum to: Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease

Mateo Sarmiento Bustamante  1 , Sheila K Pierson  1 , Yue Ren  2 , Adam Bagg  3 , Joshua D Brandstadter  4 , Gordan Srkalovic  5 , Natalie Mango  1 , Daisy Alapat  6 , Mary Jo Lechowicz  7 , Hongzhe Li  2 , Frits Van Rhee  8 , Megan S Lim  9 , David C Fajgenbaum  10
Affiliations
Published Erratum

Erratum to: Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease

Mateo Sarmiento Bustamante et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Patients with idiopathic multicentric Castleman disease demonstrate severe disease at diagnosis. (A) A large proportion of patients with idiopathic multicentric Castleman disease (iMCD) across all ages had severe disease. Notably, 94% of patients under the age of 30 years presented with severe disease at diagnosis. (B) Within the cohort of 102 iMCD patients, 87 (85.3%) had anemia and 81 (79.4%) had hypoalbuminemia at diagnosis. *Lower limit of normal for hemoglobin in males (12.5 g/dL). †Lower limit of normal for hemoglobin in females (11.5 g/dL). ‡Lower limit of normal for albumin (3.5 g/dL). (C) A large majority of patients presented with clinical symptoms, which ranged from mild to severe. Patients with both clinical subtypes of iMCD (TAFRO and NOS) demonstrated clinical abnormalities. TAFRO: thrombocytopenia, anasarca, fever/elevated C-reactive protein, reticulin fibro-sis/renal failure, and organomegaly; NOS: not otherwise specified.
Corrected Figure 3.
Corrected Figure 3.
Patients with idiopathic multicentric Castleman disease experience a range of organ system involvement, require various hospital interventions, and demonstrate ongoing flares. (A) Organ system involvement in idiopathic multicentric Castleman disease (iMCD) ranked from most frequently observed to least frequently observed. Over 97% of the iMCD cohort experienced some hematopoietic dysfunction. Notably, both patients with TAFRO (thrombocytopenia, anasarca, fever/elevated C-reactive protein, reticulin fibrosis/renal failure, and organomegaly) and those with iMCD not otherwise specified (NOS) experienced significant organ system involvement and dysfunction. (B) The severity of organ dysfunction is reflected by the degree of healthcare intervention(s) required. Over one-quarter of patients (N=27 [26.5%]) required dialysis and 17 (16.7%) patients required the use of a ventilator. Additionally, 47 (46.0%) patients required fluid removal (paracentesis), 42 (41.1%) patients received a red blood cell transfusion, and 22 (21.6%) patients received a platelet transfusion. (C) NOS patients spent a significantly greater proportion of time in flare from presentation until last known information (median [interquartile range]: 52.3% [21.0-99.6]) compared to TAFRO patients (18.9% [10.8-52.5], W=1673; P=0.004). (D) Each patient is represented by a vertical bar. The bar extends the length of follow-up from the start of the first flare. NOS patients are represented on the left, and TAFRO patients are represented on the right. The blue bars represent the proportion of time NOS patients spent in flare. The red bars represent the proportion of time TAFRO patients spent in flare. The designation ‘d’ indicates a deceased patient. RBC: red blood cells.
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References

    1. Bustamante MS, Pierson SK, Ren Y, et al. . Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease. Haematologica. 2024;109(7):2196-2206. - PMC - PubMed

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