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. 2025 May;77(5):2168-2172.
doi: 10.1007/s12070-025-05463-y. Epub 2025 Apr 10.

Ancient Schwannoma- An Unusual Sinonasal Tumour

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Ancient Schwannoma- An Unusual Sinonasal Tumour

Apoorva K V et al. Indian J Otolaryngol Head Neck Surg. 2025 May.

Abstract

Schwannomas are benign, well-encapsulated, slow-growing nerve sheath tumours composed exclusively of Schwann cells. Ancient schwannomas, a rare variant, are particularly uncommon in the head and neck region, with very few cases reported in the nasal cavity and paranasal sinuses. Here, we describe a case of a 35-year-old male who presented to our otorhinolaryngology department with complaints of right-sided nasal obstruction for the past four years. Imaging demonstrated a lesion with dimensions of 53 × 31 × 46 mm located within the right nasal cavity, involving the middle and inferior turbinate, resulting in expansion of the right osteo-meatal complex, and protruding into the maxillary antrum with thickening of the mucosa. The excision of the lesion was performed using an external approach medial maxillectomy; subsequent histological analysis unveiled the presence of an ancient schwannoma. A comprehensive analysis of existing literature was conducted, focusing on the diagnosis and treatment of this uncommon pathological entity.

Keywords: Ancient Schwannoma; Medial Maxillectomy; Sinonasal; Tumour.

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Conflict of interest statement

Conflicts of InterestThe authors declare no competing interests.

References

    1. Joshi R (2012) Learning from eponyms: Jose verocay and verocay bodies, Antoni A and B areas, Nils Antoni and schwannomas. Indian Dermatology Online J 3(3):215. 10.4103/2229-5178.101826 - DOI - PMC - PubMed
    1. Weber AL, Montandon C, Robson CD (2000) ‘Neurogenic tumors of the neck’, Radiologic Clinics of North America, 38(5), pp. 1077–1090. 10.1016/s0033-8389(05)70222-0 3. Hillstrom, R.P., Zarbo, R.J. and Jacobs, J.R. (1990) ‘Nerve sheath tumors of the paranasal sinuses: Electron microscopy and histopathologic diagnosis’, Otolaryngology–Head and Neck Surgery, 102(3), pp. 257–263. doi:10.1177/019459989010200309 - PubMed
    1. Moini J, Avgeropoulos NG, Samsam M (2021) Schwannoma. Epidemiol Brain Spinal Tumors 179–196. 10.1016/b978-0-12-821736-8.00005-4
    1. Hilton DA, Hanemann CO (2014) Schwannomas and their pathogenesis. Brain Pathol 24(3):205–220. 10.1111/bpa.12125 - DOI - PMC - PubMed
    1. Kwon Y-E (2023) Ancient Schwannoma in the Parotid gland: A case report and review of the literature. Imaging Sci Dentistry 53(3):239. 10.5624/isd.20230504 - DOI - PMC - PubMed

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