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. 2025 Apr;54(4):775-784.
doi: 10.18502/ijph.v54i4.18415.

Determinants of Medication Non-Adherence among Productive-Aged Hypertensive Patients in Indonesia: A Secondary Data Analysis of Basic Health Research Database 2018

Titik Kuntari  1 , Sani Rachman Soleman  1
Affiliations

Determinants of Medication Non-Adherence among Productive-Aged Hypertensive Patients in Indonesia: A Secondary Data Analysis of Basic Health Research Database 2018

Titik Kuntari et al. Iran J Public Health. 2025 Apr.

Abstract

Background: Medication non-adherence in hypertensive patients induced disease progressivity. Several factors contribute to non-adherence to treatment, such as multidrug prescription, the relationship between doctors and patients, and barriers in health services. We aimed to analyze determinants of medication non-adherence in productive-aged hypertensive patients in Indonesia.

Methods: A cross-sectional study was conducted among 58,148 respondents across Indonesia. Covariates are gender, age, education, occupation, residence, smoking status, family member, and history of stroke, cardiovascular and diabetes mellitus. Chi-square and Binary Logistic were performed using SPSS version 21.

Results: More than half of the 58,148 hypertension patients in Indonesia (53.9%) are not taking their medication regularly. Chi-square analysis found that male gender, age groups (25 to 34, 35 to 44, 45 to 55, 56 to 64), graduated senior high school, employed workers, living in urban, smokers, four family members, and disease history correlated with non-adherence to treatment. However, Binary Logistic is obtained that age groups age groups (25 to 34, 35 to 44, 45 to 55 and 56 to 64; AOR=1.251, 1.609, 2.179, 2.424, respectively), employed workers (AOR=0.912), urban lived (AOR=1.085), smokers (AOR=0.853), more than four family members (AOR=1.146), stroke history (AOR=1.793), cardiovascular history (AOR=1.623), and diabetes mellitus history (AOR=1.489) found their significance level at 0.00. Two variables, gender and education, are not of significant.

Conclusion: Medication non-adherence in hypertensive patients has multifactorial aspects, such as in this study, including age, employed workers, living in urban areas, smokers, more prominent family members, and the history of the disease.

Keywords: Hypertension; Indonesia; Medication non-adherence; Riset kesehatan dasar (RISKESDAS).

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Figures

Fig. 1:
Fig. 1:
Flowchart of sampling selection in participants
Fig. 2:
Fig. 2:
Medication adherence (blue) vs non-adherence (orange) hypertensive agents based on baseline characteristics
Fig. 3:
Fig. 3:
Description of percentages of medication non-adherence in hypertensive patients across 38 provinces
See this image and copyright information in PMC

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