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Case Reports
. 2025 Apr 1;17(4):e81581.
doi: 10.7759/cureus.81581. eCollection 2025 Apr.

Inclusion Body Myositis: A Case Report

Komalpreet Kaur  1 , Natalie Saliba  1 , Jitesh Kar  2
Affiliations
Case Reports

Inclusion Body Myositis: A Case Report

Komalpreet Kaur et al. Cureus. .

Abstract

Inclusion body myositis (IBM) is an autoimmune disease characterized by chronic inflammation and mainly muscular manifestations.This report details the case of a 71-year-old male presenting with gradual-onset muscle weakness in finger flexors and quadriceps, frequent falls, and muscle biopsy findings indicative of IBM. Due to a lack of curative treatments, the patient's management focuses on supportive care, physical therapy, and mobility aids to mitigate disease progression and reduce fall risk.

Keywords: autoimmune; idiopathic inflammatory myopathy; inclusion body myositis; myopathy; sporadic ibm.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Histological muscle biopsy of a patient with sporadic IBM. White arrows indicate the endomysial inflammatory reaction, while a global dystrophic pattern is observed.
The muscle biopsy was stained with hematoxylin and eosin, which stains nuclei blue and muscle fibers pink. This image was captured at 200x magnification. Source: Ref. [9].
Figure 2
Figure 2. Histological muscle biopsy of a patient with sporadic IBM. White arrow highlights the endomysial inflammatory reaction, while the black arrow indicates rimmed vacuoles.
The muscle biopsy was stained with Gomori’s trichrome, which stains muscle fibers and cytoplasm in red, nuclei in black, and collagen-containing connective tissues in blue. This image was captured at 400x magnification. Source: Ref. [9].
See this image and copyright information in PMC

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