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Case Reports
. 2025 Apr 1;17(4):e81583.
doi: 10.7759/cureus.81583. eCollection 2025 Apr.

Management of Anterior Mediastinal Hodgkin's Lymphoma in Polycystic Kidney Disease: A Case Report

Andrea N Wang  1 , Emily Heath  2 , A Rashid Dar  1 , Keng Yeow Tay  3   4 , Louise Moist  5
Affiliations
Case Reports

Management of Anterior Mediastinal Hodgkin's Lymphoma in Polycystic Kidney Disease: A Case Report

Andrea N Wang et al. Cureus. .

Abstract

This case report presents a 33-year-old male with polycystic kidney disease (PKD) who presented with superior vena cava syndrome due to an anterior mediastinal mass. Imaging and pathology confirmed a Hodgkin's lymphoma of nodular sclerosis subtype of the mediastinum. Despite chronic kidney disease, prioritization to treat the Hodgkin's lymphoma was taken with careful monitoring of renal function. Renal function declined throughout chemotherapy, necessitating modification to the chemotherapy regimen, but not requiring dialysis. Three years following remission from lymphoma, renal function continued to decline, prompting renal transplant and bilateral nephrectomy. This case highlights considerations in treatment for oncological disease with pre-existing decreased kidney function.

Keywords: chemoradiation; chronic kidney disease (ckd); hodgkin’s lymphoma; polycystic kidney disease (pkd); superior vena cava (svc) syndrome.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Anterior mediastinal mass anterior to the aortic arch, measuring 3.8 x 5.1 cm, essentially unchanged from the start of chemotherapy.
Figure 2
Figure 2. Polycystic kidney disease on ultrasound in the right kidney with a large cyst measuring 6.6 cm.
See this image and copyright information in PMC

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