Challenges in chemotherapy for head and neck cancer: A review

Abstract

Head and neck cancer (HNC) remains a global health challenge due to its high mortality and morbidity. Advances in chemotherapy, combination therapies and targeted treatments like immunotherapy, have significantly improved survival rates. These developments pave the way for personalized therapies that maximize effectiveness while minimizing toxicities. However, challenges such as tumor resistance, treatment-related side effects and limited access to advanced therapies continue to hinder progress. Addressing these issues requires efforts in clinical research, biomarker discovery and ensuring equitable access to innovative treatments worldwide.

Keywords: Head and neck squamous cell carcinoma; chemotherapy; cisplatin; clinical trials; combination therapy; immunotherapy.

Figure 1

Survival Probability over Time: head and neck squamous cell carcinoma treatments

Figure 2

ECOG 3311 three trial risk groups

Figure 3

Adverse effects across head and neck squamous cell carcinoma treatments