Paradoxical indeed

Zachary T Compton^{1

2

3}, Orsolya Vincze^{4

5}, Walker Mellon¹, Marc Tollis^{1

6}, Lisa Abegglen^{1

7}, Joshua D Schiffman⁷, Mathieu Giraudeau⁵, Amy M Boddy^{1

8}, Carlo C Maley^{1

9

10}

Affiliations

¹ Arizona Cancer Evolution Center, The Biodesign Institute, Arizona State University, Tempe, AZ 85281.
² University of Arizona Cancer Center, Tucson, AZ 85724.
³ University of Arizona College of Medicine, Tucson, AZ 85724.
⁴ Institute of Aquatic Ecology, Centre for Ecological Research, Debrecen 1113, Hungary.
⁵ LIENSs, UMR 7266 CNRS-La Rochelle Université, La Rochelle 17000, France.
⁶ School of Informatics, Computing and Cyber Systems, Northern Arizona University, Flagstaff, AZ 86001.
⁷ Department of Pediatrics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112.
⁸ University of California Santa Barbara, Santa Barbara, CA 93106.
⁹ Biodesign Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ 85724.
¹⁰ School of Life Sciences, Arizona State University, Tempe, AZ 85724.

PMID: 40324092
PMCID: PMC12088420
DOI: 10.1073/pnas.2504512122

Paradoxical indeed

Zachary T Compton et al. Proc Natl Acad Sci U S A. 2025.

. 2025 May 13;122(19):e2504512122.

doi: 10.1073/pnas.2504512122. Epub 2025 May 5.

Authors

Affiliations

¹ Arizona Cancer Evolution Center, The Biodesign Institute, Arizona State University, Tempe, AZ 85281.
² University of Arizona Cancer Center, Tucson, AZ 85724.
³ University of Arizona College of Medicine, Tucson, AZ 85724.
⁴ Institute of Aquatic Ecology, Centre for Ecological Research, Debrecen 1113, Hungary.
⁵ LIENSs, UMR 7266 CNRS-La Rochelle Université, La Rochelle 17000, France.
⁶ School of Informatics, Computing and Cyber Systems, Northern Arizona University, Flagstaff, AZ 86001.
⁷ Department of Pediatrics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112.
⁸ University of California Santa Barbara, Santa Barbara, CA 93106.
⁹ Biodesign Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ 85724.
¹⁰ School of Life Sciences, Arizona State University, Tempe, AZ 85724.

PMID: 40324092
PMCID: PMC12088420
DOI: 10.1073/pnas.2504512122

No abstract available

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Conflict of interest statement

Competing interests statement:J.D.S. is co-founder, shareholder, and employed by Peel Therapeutics, Inc., a company developing evolution-inspired medicines based on cancer resistance in elephants. L.A. is share-holder and consultant to Peel Therapeutics, Inc.

References

1. Peto R., “Epidemiology, multistage models, and short-term mutagenicity tests” in The Origins of Human Cancer, Cold Spring Harbor Conferences on Cell Proliferation, Hiatt H. H., Watson J. D., Winsten J. A., Eds. (Cold Spring Harbor Laboratory, 1977), vol. 4, pp. 1403–1428.
1. Butler G., Baker J., Amend S. R., Pienta K. J., Venditti C., No evidence for Peto’s paradox in terrestrial vertebrates. Proc. Natl. Acad. Sci. U.S.A. 122, e2422861122 (2025). - PMC - PubMed
1. Vincze O., et al. , Cancer risk across mammals. Nature 601, 263–267 (2022). - PMC - PubMed
1. Compton Z. T., et al. , Cancer prevalence across vertebrates. Cancer Discov. 15, 227–244 (2024). - PMC - PubMed
1. Tollis M., et al. , Elephant genomes reveal accelerated evolution in mechanisms underlying disease defenses. Mol. Biol. Evol. 38, 3606–3620 (2021). - PMC - PubMed

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Paradoxical indeed

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Paradoxical indeed

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