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Comment
. 2025 May 13;122(19):e2506038122.
doi: 10.1073/pnas.2506038122. Epub 2025 May 5.

Refining the role of the paraventricular hypothalamus in feeding behavior

Lisa Z Fang  1 , Michiru Hirasawa  2
Affiliations
Comment

Refining the role of the paraventricular hypothalamus in feeding behavior

Lisa Z Fang et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
In the PVH, Sim1 neurons coexpressing TH promote food intake and obesity, unlike other PVH-Sim1 neurons that induce satiety. These orexigenic PVH-TH neurons are excited by both AgRP and POMC neurons of the arcuate nucleus (ARC), likely at different phases of food consummatory behavior. Among several projection targets of PVH-TH neurons, dopamine release in the LHb at least in part accounts for the increase in food intake through activation of D2 receptors (D2R).
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