Comparative Study
doi: 10.1021/jm00147a040.
New cysteamine (2-chloroethyl)nitrosoureas. Synthesis and preliminary antitumor results
- PMID: 4032435
- DOI: 10.1021/jm00147a040
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Comparative Study
New cysteamine (2-chloroethyl)nitrosoureas. Synthesis and preliminary antitumor results
J Med Chem.
1985 Sep.
Abstract
Three chemical pathways were used for the synthesis of four new N'-(2-chloroethyl)-N-[2-(methylsulfinyl)ethyl]- and N'-(2-chloroethyl)-N-[2-(methylsulfonyl)ethyl]-N- or N'-nitrosoureas. These compounds are plasma metabolites of CNCC, a promising antineoplastic (2-chloroethyl)nitrosourea. Preliminary antitumor evaluation was performed against L1210 leukemia implanted intraperitoneally in mice. Among these compounds, two of them exhibited a greater antitumor activity compared to that of the parent mixture.
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