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. 2025 May 5;15(1):15671.
doi: 10.1038/s41598-025-00528-y.

Diagnostic value of choroidal vascular density in predicting the progression of diabetic retinopathy

Chuanjie Yin  1 , Shanshan Zhang  1 , Dong Guo  2 , Jianmin Qin  1 , Huadong Lou  3 , Guowen Zhang  1
Affiliations

Diagnostic value of choroidal vascular density in predicting the progression of diabetic retinopathy

Chuanjie Yin et al. Sci Rep. .

Abstract

By utilizing widefield swept-source optical coherence tomography angiography (WSS-OCTA) to quantify choroidal vascular density (VD) in order to identify early fundus changes in diabetic patients and to predict the progression of diabetic retinopathy (DR). A total of 101 eyes, including patients with type 2 diabetes mellitus and controls, were included in the cross-sectional study. Diabetic patients were stratified into three groups based on disease severity: non-DR (NDR), nonproliferative DR (NPDR), and proliferative DR (PDR). Fundus images obtained through WSS-OCTA were segmented into nine 2 mm × 2 mm regions centered on the macula: supratemporal (ST), superior (S), supranasal (SN), temporal (T), central macular area (C), nasal (N), inferotemporal (IT), inferior (I), and inferonasal (IN). Changes in choroidal VD in the choriocapillaris (CC) and mid-large choroidal vasculature (MLCV) layers were evaluated in each region among patients with DR. Additionally, the diagnostic value of choroidal VD in distinguishing different stages of DR was assessed using the area under the receiver operating characteristic (ROC) curve. In comparison to the NDR group, the VD of MLCV (S) was found to decrease significantly in the NPDR group. Furthermore, the VD of CC (S) was significantly lower in the PDR group compared to the NPDR group. The VD of MLCV (IN) demonstrated potential in distinguishing between healthy eyes and those with NDR. Additionally, the VD of CC (SN) and MLCV (S, SN, C, I) showed relatively high area under the curve (AUC) values in discriminating between NDR and NPDR. Lastly, the VD of CC (S) exhibited good diagnostic accuracy in distinguishing between NPDR and PDR patients. As DR advances, MLCV and CC are sequentially compromised to varying degrees. In clinical diagnosis, the VD of the IN region in the MLCV layer serves as a more sensitive early imaging biomarker for detecting preclinical DR, while a decrease in the VD of the S region in the CC layer indicates the onset of PDR.

Keywords: Choroidal vascular density; Diabetes mellitus; Diabetic retinopathy; Receiver operating characteristic; Widefield swept-source optical coherence tomography angiography.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The studies involving human participants were reviewed and approved by Ethics Committee of Qingdao Eighth People’s Hospital (No. QBYLL-KY-2024-002). The patients/participants provided their written informed consent to participate in this study.

Figures

Fig. 1
Fig. 1
The OCTA images of the choroidal vascular density of Choriocapillaris (CC) and Mid-large choroidal vasculature (MLCV) in different groups of left eyes.
Fig. 2
Fig. 2
The ROC curve for the choroidal vascular density between CON and NDR groups.
Fig. 3
Fig. 3
The ROC curve for the choroidal vascular density between NDR and NPDR groups. Note: Combined parameters: The predictive probabilities derived from multiple logistic regression modeling of VD in the NDR and NPDR groups described above.
Fig. 4
Fig. 4
The ROC curve for the choroidal vascular density between NPDR and PDR groups.
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