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Editorial
. 2025 Jun;17(9):575-577.
doi: 10.1080/17501911.2025.2500914. Epub 2025 May 6.

Selective chemical tracking of DNA methylomes in live cells

Affiliations
Editorial

Selective chemical tracking of DNA methylomes in live cells

Vaidotas Stankevičius et al. Epigenomics. 2025 Jun.
No abstract available

Keywords: DNA methylation; DNMT1; catalysis-dependent DNA labeling; embryonic stem cells; epigenomic tools; methyltransferase reaction engineering; synthetic AdoMet analogs.

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Conflict of interest statement

Giedrius Vilkaitis and Saulius Klimašauskas are inventors on licensed patents related to the mTAG technology. Saulius Klimašauskas is a technical advisor for Tagomics Ltd. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

References

    1. Falnes PØ. Closing in on human methylation—the versatile family of seven-β-strand (METTL) methyltransferases. Nucleic Acids Res. 2024;52(19):11423–11441. doi: 10.1093/nar/gkae816 - DOI - PMC - PubMed
    1. Ma T, Zhang Q, Zhang S, et al. Research progress of human key DNA and RNA methylation-related enzymes assay. Talanta. 2024;273:125872. doi: 10.1016/j.talanta.2024.125872 - DOI - PubMed
    1. Ehrlich M. DNA hypermethylation in disease: mechanisms and clinical relevance. Epigenetics. 2019;14(12):1141–1163. doi: 10.1080/15592294.2019.1638701 - DOI - PMC - PubMed
    1. Chen Q, Liu B, Zeng Y, et al. GSK-3484862 targets DNMT1 for degradation in cells. NAR Cancer. 2023;5(2):zcad022. doi: 10.1093/narcan/zcad022 - DOI - PMC - PubMed
    1. Scelfo A, Barra V, Abdennur N, et al. Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization. J Cell Biol. 2024;223(4):e202307026. doi: 10.1083/jcb.202307026 - DOI - PMC - PubMed

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