Proximal Tubule Cells Contribute to the Thin Descending Limb of the Loop of Henle during Mouse Kidney Development

Eunah Chung^{1

2}, Fariba Nosrati^{1

2}, Mike Adam³, Andrew Potter⁴, Mohammed Sayed⁵, Christopher Ahn⁵, Benjamin D Humphreys^{6

7}, Hee-Woong Lim^{5

8}, Yueh-Chiang Hu^{3

8}, S Steven Potter^{3

8}, Joo-Seop Park^{1

2}

Affiliations

¹ Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
² Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁴ Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁵ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁶ Division of Nephrology, Department of Medicine, Washington University, St. Louis, Missouri.
⁷ Department of Developmental Biology, Washington University, St. Louis, Missouri.
⁸ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Eunah Chung et al. J Am Soc Nephrol. 2025.

. 2025 May 6.

doi: 10.1681/ASN.0000000721. Online ahead of print.

¹ Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
² Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁴ Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁵ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁶ Division of Nephrology, Department of Medicine, Washington University, St. Louis, Missouri.
⁷ Department of Developmental Biology, Washington University, St. Louis, Missouri.
⁸ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

No abstract available

Keywords: genetic diseases and development; genetics and development; kidney development; nephron development; renal development.

Update of

Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development.
Chung E, Nosrati F, Adam M, Potter A, Sayed M, Ahn C, Humphreys BD, Lim HW, Hu YC, Potter SS, Park JS. Chung E, et al. bioRxiv [Preprint]. 2025 Mar 24:2025.01.14.633065. doi: 10.1101/2025.01.14.633065. bioRxiv. 2025. Update in: J Am Soc Nephrol. 2025 May 6. doi: 10.1681/ASN.0000000721. PMID: 39868227 Free PMC article. Updated. Preprint.

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