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Case Reports
. 2025 May 6;113(1):32-36.
doi: 10.4269/ajtmh.24-0553. Print 2025 Jul 2.

Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid

Jill Teitelbaum  1 , Shivank Madan  1   2 , Snehal Patel  1   2 , Christina Coyle  1 , Charles Y Chiu  3 , Phyu M Thwe  1   2 , Mayuko Uehara  2 , Rita Jermyn  2 , Vagish Hemmige  1   2
Affiliations
Case Reports

Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid

Jill Teitelbaum et al. Am J Trop Med Hyg. .

Abstract

Chagas meningoencephalitis can present in immunocompromised patients after organ transplantation. We present the first reported instance in which metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid diagnosed Chagas meningoencephalitis in a patient. The diagnosis of Chagas in this case underscores the role of mNGS in identifying rare or unexpected pathogens.

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Conflict of interest statement

Disclosures: C. Y. Chiu is a co-founder of Delve Bio and serves on the scientific advisory boards for Delve Bio, Flightpath Biosciences, Biomeme, Mammoth Biosciences, BiomeSense, and Poppy Health. C. Y. Chiu receives research support from Delve Bio and Abbott Laboratories, Inc. V. Hemmige received funding from Merck for a pneumococcal vaccine study. Informed consent was obtained from the patient.

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