Clinical Manifestations and Treatment Response of Patients With Syndrome of Undifferentiated Recurrent Fever (SURF)

Emma Longoni¹, Riccardo Papa¹, Francesca Bovis², Bianca Laura Cinicola³, Riccardo Castagnoli^{4

5}, Caterina Cancrini^{6

7}, Francesca Conti^{8

9}, Silvia Federici¹⁰, Anna Bratta¹, Giuliana Giardino¹¹, Lucia Leonardi¹², Vassilios Lougaris¹², Maria Sangerardi¹³, Annarosa Soresina¹⁴, Gian Luigi Marseglia^{4

5}, Michele Miraglia Del Giudice¹⁵, Marco Gattorno¹, Fabio Cardinale¹⁶; Immunology Task Force of the Italian Society of Pediatric Allergy and Immunology (SIAIP)

Affiliations

¹ UOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genova, Italy.
² Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
³ Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
⁴ Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.
⁵ Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁶ Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
⁷ Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁸ Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
⁹ Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
¹⁰ Division of Rheumatology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
¹¹ Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
¹² Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
¹³ Department of Pediatric Emergency Medicine, Policlinico-"Giovanni XXIII" Pediatric Hospital of Bari, University of Bari, Bari, Italy.
¹⁴ Unit of Pediatric Immunology, Pediatrics Clinic, University of Brescia, ASST Spedali Civili Brescia, Brescia, Italy.
¹⁵ Department of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
¹⁶ Department of Pediatrics, Regional Referral Center in Pediatric Immunology and Rheumatology, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.

PMID: 40329620
DOI: 10.1111/1756-185X.70246

Editorial

Clinical Manifestations and Treatment Response of Patients With Syndrome of Undifferentiated Recurrent Fever (SURF)

Emma Longoni et al. Int J Rheum Dis. 2025 May.

. 2025 May;28(5):e70246.

doi: 10.1111/1756-185X.70246.

Authors

Affiliations

¹ UOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genova, Italy.
² Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
³ Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
⁴ Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.
⁵ Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁶ Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
⁷ Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁸ Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
⁹ Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
¹⁰ Division of Rheumatology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
¹¹ Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
¹² Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
¹³ Department of Pediatric Emergency Medicine, Policlinico-"Giovanni XXIII" Pediatric Hospital of Bari, University of Bari, Bari, Italy.
¹⁴ Unit of Pediatric Immunology, Pediatrics Clinic, University of Brescia, ASST Spedali Civili Brescia, Brescia, Italy.
¹⁵ Department of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
¹⁶ Department of Pediatrics, Regional Referral Center in Pediatric Immunology and Rheumatology, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.

PMID: 40329620
DOI: 10.1111/1756-185X.70246

No abstract available

Keywords: autoinflammatory diseases; colchicine; genetics; immunology; innate immunity; recurrent fever.

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References

1. R. Papa, R. Caorsi, S. Volpi, and M. Gattorno, “Expert Perspective: Diagnostic Approach to the Autoinflammatory Diseases,” Arthritis & Rhematology 76 (2024): 166–177.
1. H. J. Lachmann, “Periodic Fever Syndromes,” Best Practice & Research. Clinical Rheumatology 31 (2017): 596–609.
1. “Orphanet,” accessed March 24, 2024, https://www.orpha.net.
1. M. Labrousse, C. Kevorkian‐Verguet, G. Boursier, et al., “Mosaicism in Autoinflammatory Diseases: Cryopyrin‐Associated Periodic Syndromes (CAPS) and Beyond. A Systematic Review,” Critical Reviews in Clinical Laboratory Sciences 55 (2018): 432–442.
1. J. B. Kuemmerle‐Deschner, D. Verma, T. Endres, et al., “Brief Report: Clinical and Molecular Phenotypes of Low‐Penetrance Variants of NLRP3: Diagnostic and Therapeutic Challenges,” Arthritis & Rheumatism 69, no. 11 (2017): 2233–2240, https://doi.org/10.1002/art.40208.

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Clinical Manifestations and Treatment Response of Patients With Syndrome of Undifferentiated Recurrent Fever (SURF)

Affiliations

Clinical Manifestations and Treatment Response of Patients With Syndrome of Undifferentiated Recurrent Fever (SURF)

Authors

Affiliations

References

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