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. 2024 Apr:2024:MS1A.2.
doi: 10.1364/MICROSCOPY.2024.MS1A.2.

GigaFIBI; Rapid, Large-format Histology-resolution Imaging for Intraoperative Assessment of Breast Lumpectomy Margins

Dena Sayrafi  1 , Nate Anderson  1 , Candice Sauder  2 , Diana Miglioretti  3 , Richard Levenson  1 , Alexander Borowsky  1 , Farzad Fereidouni  1
Affiliations

GigaFIBI; Rapid, Large-format Histology-resolution Imaging for Intraoperative Assessment of Breast Lumpectomy Margins

Dena Sayrafi et al. Biomed Opt. 2024 Apr.

Abstract

GigaFIBI, an advancement of Fluorescence Imitating Brightfield Imaging (FIBI), displays significant promise in reducing positive margins and associated costs by capturing histology-grade images of 100×100 within minutes, offering intraoperative guidance.

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Figures

Fig 1.
Fig 1.
Optics required for FIBI imaging(A), and representative images from a lobular carcinoma breast cancer specimen(B) with close-ups demonstrating the appearance of a normal breast lobule(C).
Fig 2.
Fig 2.
Mammary carcinoma, comparing FIBI (Left) to H&E (right). Higher magnification of a typical lobule depicted in the lower row.
See this image and copyright information in PMC

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References

    1. Borowsky AD, Levenson RM, Gown AM, Morningstar T, Fleury TA, Henderson G, Schaberg K, Sybenga AB, Glassy EF, Taylor SL, “A Pilot Validation Study Comparing Fluorescence-Imitating Brightfield Imaging, A Slide-Free Imaging Method, With Standard Formalin-Fixed, Paraffin-Embedded Hematoxylin-Eosin–Stained Tissue Section Histology for Primary Surgical Pathology Diagnosis,” Archives of Pathology & Laboratory Medicine (2023). - PMC - PubMed
    1. Siegel R, Miller K, Fuchs H, Jemal A, Cancer statistics, 2021 (vol 71, pg 7, 2021), CA-A CANCER JOURNAL FOR CLINICIANS 71 (2021) 359–359. - PubMed
    1. Landercasper J, Whitacre E, Degnim AC, Al-Hamadani M, “Reasons for re-excision after lumpectomy for breast cancer: insight from the American Society of Breast Surgeons Mastery SM database”, Annals of surgical oncology 21 (2014) 3185–3191. - PubMed
    1. Jeevan R, Cromwell D, Trivella M, Lawrence G, Kearins O, Pereira J, Sheppard C, Caddy C, Van Der Meulen J,” Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics”, Bmj 345 (2012) e4505. - PMC - PubMed
    1. Huston TL, Pigalarga R, Osborne MP, Tousimis E, “The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery”, The American journal of surgery 192 (2006) 509–512. - PubMed

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