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. 2024 Apr:2024:MS1A.2.
doi: 10.1364/MICROSCOPY.2024.MS1A.2.

GigaFIBI; Rapid, Large-format Histology-resolution Imaging for Intraoperative Assessment of Breast Lumpectomy Margins

Dena Sayrafi  1 , Nate Anderson  1 , Candice Sauder  2 , Diana Miglioretti  3 , Richard Levenson  1 , Alexander Borowsky  1 , Farzad Fereidouni  1
Affiliations

GigaFIBI; Rapid, Large-format Histology-resolution Imaging for Intraoperative Assessment of Breast Lumpectomy Margins

Dena Sayrafi et al. Biomed Opt. 2024 Apr.

Abstract

GigaFIBI, an advancement of Fluorescence Imitating Brightfield Imaging (FIBI), displays significant promise in reducing positive margins and associated costs by capturing histology-grade images of 100×100 within minutes, offering intraoperative guidance.

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Figures

Fig 1.
Fig 1.
Optics required for FIBI imaging(A), and representative images from a lobular carcinoma breast cancer specimen(B) with close-ups demonstrating the appearance of a normal breast lobule(C).
Fig 2.
Fig 2.
Mammary carcinoma, comparing FIBI (Left) to H&E (right). Higher magnification of a typical lobule depicted in the lower row.
See this image and copyright information in PMC

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