Advancements in toxicological risk assessment: integrating Ferguson's principle, computational models, and drug safety guidelines, a comprehensive framework for improving risk assessment and resource management in toxicology

Abstract

This investigative study examines the transfer of maternal medications into breast milk and their potential impact on breastfeeding infants. Significant factors influencing drug transfer, including physiochemical properties and milk composition, are analysed to corroborate judicious drug administration in nursing mothers. The study investigates, evaluates, and interprets drugs such as: H|chlorpromazine (New England Nuclear [NEN]), diazepam Roche, C|diclofenac (Ciba-Geigy, 6.6 mCi/mmol, K-277), diclofenac (Ciba-Geigy, 0.1317), digoxin (Wellcome, 11725), fluphenazine (Squibb 12240), phenytoin (NEN, 46 Ci/mmol, 2315-061), phenytoin (Parke-Davis 5419972), pirenzepine (Boehringer-Ingelheim-660206), H|prednisolone (Amersham, 67.4 Ci/mmol, 88), warfarin (Amersham, 46 mCi/mmol, 30), outlining and assessing their transferability and perils notably presented. Ferguson's principle was leveraged to predict drug toxicity, specifically for central nervous system depressants, elucidating drug lethality and safety evaluation. On top of that, advancements in toxicological risk assessment were evaluated, articulated as focusing on naloxone programs, predictive modelling, quantitative structure-activity relationship (QSAR) applications, toxicogenomics, and ordinary differential equation (ODE) models. The comparison between risk assessments and biological monitoring highlights the prominence of evaluating internal dosages. Progress in 3D-QSAR modelling augmented its role in forecasting chemical toxicity, while advancements in toxicogenomics and the application of ODE models have contributed to toxicological research. Hence, the shift toward alternate toxicity assessment methodologies was driven by ethical concerns, budgetary limits, and the demand for more human-relevant data without sacrificing an animal life, which was a concern of the present scientific investigation; fixed by machine algorithms, e.g. random forest, Support Vector Machine (SVM), Ferguson's principle, etc.; an omics data set for correlation through tactile programmed computational heuristics for decision science.

Keywords: Ferguson’s principle; breastfeeding; drug lethality; lethal concentrations; maternal medication use; toxicity prediction.