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. 2025 Jul 10;146(2):254-259.
doi: 10.1182/blood.2024027368.

ANKRD26-related thrombocytopenia 2 with a baseline increase in blasts: implications for clinical surveillance

Lara Wahlster  1 , Lucy A Godley  2 , Jason X Cheng  3 , Michael W Drazer  4 , Christopher R Reilly  5 , Geraldine S Pinkus  6 , Jared H Rowe  1 , Nina Weichert-Leahey  1 , R Grant Rowe  1 , Lev Gorfinkel  1 , Karyn Brundige  1 , Franziska Wachter  1 , Luana Messa  1 , Alan D Michelson  1 , Alan B Cantor  1 , Akiko Shimamura  1 , Jacob R Bledsoe  7
Affiliations

ANKRD26-related thrombocytopenia 2 with a baseline increase in blasts: implications for clinical surveillance

Lara Wahlster et al. Blood. .

Abstract

We report on 8 patients with ankyrin repeat domain 26 (ANKRD26)-related thrombocytopenia 2 (ANKRD26-RT) with elevated bone marrow myeloblasts and dysmegakaryopoiesis, without somatic genetic abnormalities or progression to malignancy during long-term observation, findings which may constitute inherent ANKRD26-RT biology rather than progression to myeloid malignancy.

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Conflict of interest statement

Conflict-of-interest disclosure: J.R.B. serves on the scientific advisory board and has a research agreement with X4 Pharmaceuticals, unrelated to this work. A.S. serves on the advisory board for X4 Pharmaceuticals and a steering committee for Novartis, unrelated to this work. The remaining authors declare no competing financial interests.

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References

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