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Editorial
. 2025 Apr 18;26(8):3844.
doi: 10.3390/ijms26083844.

Special Issue "Depression: From Molecular Basis to Therapy"

Affiliations
Editorial

Special Issue "Depression: From Molecular Basis to Therapy"

Terezia Kiskova et al. Int J Mol Sci. .

Abstract

Depression, often described as the "silent epidemic" of the 21st century, stands as a complex and pervasive mental health challenge that affects millions of individuals worldwide [...].

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The various mechanisms involved in the pathophysiology of depression. VTA—ventral tegmental area; NAC—nucleus accumbens; MSNs—medium spiny neurons; TNFα—tumor necrosis factor alpha; IL—interleukin; TLR—Toll-like receptor; INFγ—interferon gamma; NLRP—nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin-containing domain. Created with BioRender.com.

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References

    1. Cui L., Li S., Wang S., Wu X., Liu Y., Yu W., Wang Y., Tang Y., Xia M., Li B. Major depressive disorder: Hypothesis, mechanism, prevention and treatment. Signal Transduct. Target. Ther. 2024;9:30. doi: 10.1038/s41392-024-01738-y. - DOI - PMC - PubMed
    1. Luca A., Luca M., Kasper S., Pecorino B., Zohar J., Souery D., Montgomery S., Ferentinos P., Rujescu D., Messina A., et al. Anhedonia is associated with a specific depression profile and poor antidepressant response. Int. J. Neuropsychopharmacol. 2024;27:pyae055. doi: 10.1093/ijnp/pyae055. - DOI - PMC - PubMed
    1. WHO Mental Health Atlas. [(accessed on 28 March 2025)]. Available online: https://www.who.int/teams/mental-health-and-substance-use/data-research/....
    1. Danielsson K., Ahlborg M., Mortazavi R., Jarbin H., Larsson I. Depression in adolescence and the understanding of health-A phenomenographic study. PLoS ONE. 2025;20:e0318061. doi: 10.1371/journal.pone.0318061. - DOI - PMC - PubMed
    1. Overall J.E. Methodologic issues in the epidemiology of treatment resistant depression. Contribution to epidemiology. Pharmakopsychiatr. Neuropsychopharmakol. 1974;7:129–138. doi: 10.1055/s-0028-1094411. - DOI - PubMed

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