Histologic Features Associated with Kidney Survival in Scleroderma Renal Crisis

Yannick Binois^{1

2}, David Buob³, Marie-Sophie Meuleman^{4

5}, Idris Boudhabhay^{2

4

5}, Pierre Isnard⁶, Marion Rabant⁶, Viviane Gnemmi⁷, Laurent Daniel⁸, Isabelle Brocheriou⁹, Clement Gosset¹⁰, Marie Frimat¹¹, Thomas Quémeneur¹², Rafik Mesbah¹³, Noemie Jourde-Chiche¹⁴, Olivier Moranne¹⁵, Pierre Housset¹⁶, Emmanuel Esteve¹⁷, Alexis Mathian¹⁸, Sebastien Rivière¹⁹, Aurélie Hummel²⁰, Luc Mouthon^{2

21}, Benjamin Chaigne^{2

21}, Anne-Lyse Langlois¹, Eric Thervet^{1

2}, Olivier Aubert^{2

20}, Lubka Roumenina^{4

5}, Sophie Chauvet^{1

2

4

5}, Alexandre Karras^{1

2}, Jean-Paul Duong-Van-Huyen^{2

4

5

6}

Affiliations

¹ AP-HP, Nephrology Department, European Georges Pompidou Hospital, Paris, France.
² Paris Cité University, Health Science, Paris, France.
³ AP-HP, Pathology Department, Tenon Hospital, Paris, France.
⁴ INSERM UMRS1138 team "Inflammation, Complement and cancer," Cordeliers Research Center, Paris, France.
⁵ University Hospital Federation (FHU) COMET, Paris, France.
⁶ AP-HP, Pathology Department, Necker- Enfants malades Hospital, Paris, France.
⁷ Pathology Department, Lille University Hospital Center, Lille, France.
⁸ C2VN, INSERM, INRAE et AP-HM, Centre de Néphrologie et Transplantation Rénale, CHU de la Conception, Aix-Marseille University, Marseille, France.
⁹ AP-HP, Pathology Department, La Pitié Salpêtrière Hospital, Paris, France.
¹⁰ Nephrology Department, La Réunion University Hospital Center, Saint-Denis, France.
¹¹ CHU Lille, Nephrology Department, Inserm U1167 - RID-AGE, University of Lille, Lille, France.
¹² Nephrology Department, Valenciennes Hospital Center, Valenciennes, France.
¹³ Nephrology Department, Boulogne Sur Mer Hospital Center, Boulogne Sur Mer, France.
¹⁴ AP-HM, Nephrology Department, La Conception Hospital, Marseille, France.
¹⁵ Service Nephrologie-Dialyse-Aphérèse, CHU Carémeau, Université de Montpellier-Nîmes, Nîmes, France.
¹⁶ Nephrology Department, Centre Hospitalier Sud Francilien Hospital, Corbeil-Essonnes, France.
¹⁷ APHP, Nephrology Department, Nephrology and Dialysis, Sorbonne University, INSERM U1155 Corakid, Hopital Tenon, Paris, France.
¹⁸ AP-HP, Internal Medicine Department, La Pitié Salpêtrière Hospital, Paris, France.
¹⁹ Service de Médecine Interne, AP-HP, Hôpital Saint Antoine, Sorbonne Université, Paris, France.
²⁰ AP-HP, Nephrology Department, Necker - Enfants malades Hospital, Paris, France.
²¹ AP-HP, Internal Medicine Department, Cochin Hospital, Paris, France.

PMID: 40333024
DOI: 10.1681/ASN.0000000720

Histologic Features Associated with Kidney Survival in Scleroderma Renal Crisis

Yannick Binois et al. J Am Soc Nephrol. 2025.

. 2025 May 7.

doi: 10.1681/ASN.0000000720. Online ahead of print.

Authors

Affiliations

¹ AP-HP, Nephrology Department, European Georges Pompidou Hospital, Paris, France.
² Paris Cité University, Health Science, Paris, France.
³ AP-HP, Pathology Department, Tenon Hospital, Paris, France.
⁴ INSERM UMRS1138 team "Inflammation, Complement and cancer," Cordeliers Research Center, Paris, France.
⁵ University Hospital Federation (FHU) COMET, Paris, France.
⁶ AP-HP, Pathology Department, Necker- Enfants malades Hospital, Paris, France.
⁷ Pathology Department, Lille University Hospital Center, Lille, France.
⁸ C2VN, INSERM, INRAE et AP-HM, Centre de Néphrologie et Transplantation Rénale, CHU de la Conception, Aix-Marseille University, Marseille, France.
⁹ AP-HP, Pathology Department, La Pitié Salpêtrière Hospital, Paris, France.
¹⁰ Nephrology Department, La Réunion University Hospital Center, Saint-Denis, France.
¹¹ CHU Lille, Nephrology Department, Inserm U1167 - RID-AGE, University of Lille, Lille, France.
¹² Nephrology Department, Valenciennes Hospital Center, Valenciennes, France.
¹³ Nephrology Department, Boulogne Sur Mer Hospital Center, Boulogne Sur Mer, France.
¹⁴ AP-HM, Nephrology Department, La Conception Hospital, Marseille, France.
¹⁵ Service Nephrologie-Dialyse-Aphérèse, CHU Carémeau, Université de Montpellier-Nîmes, Nîmes, France.
¹⁶ Nephrology Department, Centre Hospitalier Sud Francilien Hospital, Corbeil-Essonnes, France.
¹⁷ APHP, Nephrology Department, Nephrology and Dialysis, Sorbonne University, INSERM U1155 Corakid, Hopital Tenon, Paris, France.
¹⁸ AP-HP, Internal Medicine Department, La Pitié Salpêtrière Hospital, Paris, France.
¹⁹ Service de Médecine Interne, AP-HP, Hôpital Saint Antoine, Sorbonne Université, Paris, France.
²⁰ AP-HP, Nephrology Department, Necker - Enfants malades Hospital, Paris, France.
²¹ AP-HP, Internal Medicine Department, Cochin Hospital, Paris, France.

PMID: 40333024
DOI: 10.1681/ASN.0000000720

No abstract available

Keywords: AKI; acute kidney failure; nephrology; renal pathology.

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References

1. Teixeira L, Mouthon L, Mahr A, et al.; Group Français de Recherche sur le Sclérodermie GFRS. Mortality and risk factors of scleroderma renal crisis: a French retrospective study of 50 patients. Ann Rheum Dis. 2008;67(1):110–116. doi: 10.1136/ard.2006.066985 - DOI
1. Steen VD, Medsger TA. Changes in causes of death in systemic sclerosis, 1972–2002. Ann Rheum Dis. 2007;66(7):940–944. doi: 10.1136/ard.2006.066068 - DOI
1. Teixeira L, Mahr A, Berezné A, Noël L-H, Guillevin L, Mouthon L. Scleroderma renal crisis, still a life-threatening complication. Ann N Y Acad Sci. 2007;1108:249–258. doi: 10.1196/annals.1422.027 - DOI
1. Helfrich DJ, Banner B, Steen VD, Medsger TA. Normotensive renal failure in systemic sclerosis. Arthritis Rheum. 1989;32(9):1128–1134. doi: 10.1002/anr.1780320911 - DOI
1. Kovalchik MT, Guggenheim SJ, Silverman MH, Robertson JS, Steigerwald JC. The kidney in progressive systemic sclerosis: a prospective study. Ann Intern Med. 1978;89(6):881–887. doi: 10.7326/0003-4819-89-6-881 - DOI

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Histologic Features Associated with Kidney Survival in Scleroderma Renal Crisis

Affiliations

Histologic Features Associated with Kidney Survival in Scleroderma Renal Crisis

Authors

Affiliations

References

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