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. 2025 Jun 13;31(6):1740-1742.
doi: 10.1093/ibd/izaf084.

Understanding Pouch-Related Fistulae: Don't Lose Track of Time

Sergio Bronze  1 , Serre-Yu Wong  2 , Haley Waite  2 , Sergey Khaitov  3 , Michael Plietz  3 , Sue Hahn  3 , Alexander Greenstein  3 , Patricia Sylla  3 , Jean-Frederic Colombel  2 , Maia Kayal  2
Affiliations

Understanding Pouch-Related Fistulae: Don't Lose Track of Time

Sergio Bronze et al. Inflamm Bowel Dis. .
No abstract available

Keywords: fistula; pouch; ulcerative colitis.

Plain language summary

Patients with early-onset pouch-related fistula (PRF) within 12 months of surgery had significantly higher rates of postoperative anastomotic leakage and abscess, while patients with late-onset PRF had significantly higher rates of Crohn’s-disease-like pouch inflammation.

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Conflict of interest statement

S.B., H.W., M.P., S.H., S.K., P.S., and A.G. have no conflicts to disclose. S.Y.W. has a research contract with Takeda/Trinetx; advisory board: BMS. J.F.C. reports receiving research grants from AbbVie, Janssen Pharmaceuticals, Prometheus, Takeda, and Bristol Myers Squibb; receiving payment for lectures from AbbVie, and Takeda; receiving consulting fees from AbbVie, Amgen, AnaptysBio, Allergan, Arena Pharmaceuticals, Boehringer Ingelheim, Bristol Myers Squibb, Celgene Corporation, Celltrion, Eli Lilly, Ferring Pharmaceuticals, Galmed Research, Glaxo Smith Kline, Genentech (Roche), Janssen Pharmaceuticals, Kaleido Biosciences, Immunic, Invea, Iterative Scopes, Merck, Landos, Microba Life Science, Novartis, Otsuka Pharmaceutical, Pfizer, Protagonist Therapeutics, Prometheus, Sanofi, Seres, Takeda, Teva, TiGenix, Vifor; and hold stock options in Intestinal Biotech Development. M.K. has served as a consultant or received advisory board fees from AbbVie, Pfizer, BMS, Johnson & Johnson, and Fresenius Kabi.

References

    1. Reza LM, Lung PFC, Lightner AL, Hart AL, Clark SK, Tozer PJ.. Perianal fistula and the ileoanal pouch – different aetiologies require distinct evaluation. Colorectal Dis. 2020;22(10):1436-1439. doi: https://doi.org/ 10.1111/codi.15074 - DOI - PubMed
    1. Fazio VW, Tekkis PP, Remzi F, et al. Quantification of risk for pouch failure after ileal pouch anal anastomosis surgery. Ann Surg. 2003;238(4):605-14; discussion 614. doi: https://doi.org/ 10.1097/01.sla.0000090940.39838.6a - DOI - PMC - PubMed
    1. Kjaer MD, Kjeldsen J, Qvist N.. Poor outcomes of complicated pouch-related fistulas after ileal pouch-anal anastomosis surgery. Scand J Surg. 2016;105(3):163-167. doi: https://doi.org/ 10.1177/1457496915613648 - DOI - PubMed
    1. Ozuner G, Hull T, Lee P, Fazio VW.. What happens to a pelvic pouch when a fistula develops? Dis Colon Rectum. 1997;40(5):543-547. doi: https://doi.org/ 10.1007/BF02055375 - DOI - PubMed
    1. Arai K, Koganei K, Kimura H, et al. Incidence and outcome of complications following restorative proctocolectomy. Am J Surg. 2005;190(1):39-42. doi: https://doi.org/ 10.1016/j.amjsurg.2005.05.001 - DOI - PubMed

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