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. 2025 May;10(5):105055.
doi: 10.1016/j.esmoop.2025.105055. Epub 2025 May 6.

Promoting large multinational academic clinical trials for gastrointestinal cancers in Europe: the ENGIC (European Network for GI Cancers) initiative

J Taieb  1 , J Seligmann  2 , D Modest  3 , C Girault  4 , F Rivera  5 , E Mahillo  5 , P Osterlund  6 , P Pfeiffer  6 , D Malka  7 , C Louvet  7 , A R Siebenhuner  8 , C Morf  8 , C de la Fouchardiere  9 , L Monard  9 , M Koopman  10 , G Vink  10 , I Borbath  11 , L Dewever  11 , R Adams  2 , A Reinacher-Schick  3 , F Pietrantonio  11 , S Lonardi  12 , T Aparicio  4 , C Cremolini  12 ; ENGIC members
Collaborators, Affiliations

Promoting large multinational academic clinical trials for gastrointestinal cancers in Europe: the ENGIC (European Network for GI Cancers) initiative

J Taieb et al. ESMO Open. 2025 May.

Abstract

This paper outlines proposals for the setup of a European Network for Gastro-Intestinal Cancers (ENGIC) initiative, aiming at promoting and fostering strategic academic clinical trials for gastrointestinal cancers in Europe. We discuss the presentation of the network, its main objectives, organization, internal/external processes, operational activities, governance and, finally, priority actions for the future. We propose that this provides a model that could be adopted by researchers working in other disease areas.

Keywords: European research network; clinical trials; gastrointestinal tumours; molecular oncology; precision medicine.

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Conflict of interest statement

Disclosure The authors have declared no conflicts of interest.

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Figure 1
Figure 1
Centralized and decentralized research models. EU, European Union.
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